US 11,890,393 B2
Methods and devices for in situ formed nerve cap
Corinne Bright, Mountain View, CA (US); Yong Ren, Mountain View, CA (US); Kenneth M. Martin, Mountain View, CA (US); Farhad Khosravi, Sunnyvale, CA (US); and Amarpreet S. Sawhney, Lexington, MA (US)
Assigned to Tulavi Therapeutics, Inc., Los Gatos, CA (US); and Incept, LLC, Campbell, CA (US)
Filed by Tulavi Therapeutics, Inc., Los Gatos, CA (US); and Incept, LLC, Campbell, CA (US)
Filed on Dec. 30, 2020, as Appl. No. 17/138,703.
Application 17/138,703 is a continuation of application No. PCT/US2019/040429, filed on Jul. 2, 2019.
Claims priority of provisional application 62/822,881, filed on Mar. 24, 2019.
Claims priority of provisional application 62/692,858, filed on Jul. 2, 2018.
Prior Publication US 2021/0187160 A1, Jun. 24, 2021
Int. Cl. A61B 17/11 (2006.01); A61F 2/00 (2006.01); A61F 2/02 (2006.01); A61K 9/00 (2006.01); A61L 27/52 (2006.01); A61L 31/14 (2006.01); A61B 17/00 (2006.01); A61L 27/26 (2006.01); A61L 27/18 (2006.01)
CPC A61L 27/26 (2013.01) [A61B 17/1128 (2013.01); A61F 2/00 (2013.01); A61F 2/02 (2013.01); A61K 9/0004 (2013.01); A61L 27/18 (2013.01); A61L 27/52 (2013.01); A61L 31/14 (2013.01); A61B 2017/00526 (2013.01); A61F 2210/00 (2013.01); A61F 2210/008 (2013.01); A61F 2240/00 (2013.01); A61F 2240/001 (2013.01); A61F 2250/00 (2013.01); A61L 2400/06 (2013.01); A61L 2430/32 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of in situ formation of a nerve cap, the method comprising the steps of:
identifying a severed end of a nerve;
positioning the severed end into a cavity defined by a form;
introducing media into the cavity to surround the severed end; and
permitting the media to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end; wherein the transformation occurs within about 10 seconds of the introducing step; wherein the form is composed of a nondegradable material that can be removed from the surgical site after the media is transformed to the second, relatively non flowable state to form the protective barrier surrounding the severed end.