	US 11,890,392 B2
	Absorbable bone wax and preparation method thereof
Yong Lan, Guangdong (CN); Yu Liu, Guangdong (CN); and Yu Chen, Guangdong (CN)
Assigned to GUANGZHOU BEOGENE BIOTECHNOLOGY CO., LTD., Guangzhou (CN)
Appl. No. 17/267,024
Filed by GUANGZHOU BEOGENE BIOTECHNOLOGY CO., LTD., Guangdong (CN)
PCT Filed Dec. 20, 2019, PCT No. PCT/CN2019/127054 § 371(c)(1), (2) Date Feb. 9, 2021, PCT Pub. No. WO2021/027219, PCT Pub. Date Feb. 18, 2021.
Claims priority of application No. 201910757496.X (CN), filed on Aug. 15, 2019.
Prior Publication US 2021/0393848 A1, Dec. 23, 2021
Int. Cl. A61L 24/00 (2006.01); A61L 24/02 (2006.01); A61L 24/06 (2006.01); C08L 87/00 (2006.01); C08L 3/02 (2006.01)

CPC A61L 24/0042 (2013.01) [A61L 24/0015 (2013.01); A61L 24/02 (2013.01); A61L 24/06 (2013.01); C08L 3/02 (2013.01); C08L 87/005 (2013.01); A61L 2300/104 (2013.01); A61L 2300/204 (2013.01); A61L 2400/04 (2013.01); A61L 2430/02 (2013.01)]

15 Claims

1. A method of preparing a bone repair material, comprising:

(1) preparing a dopamine solution by dissolving dopamine hydrochloride in Tris-HCl buffer;

(2) adding β-tricalcium phosphate to the dopamine solution obtained in step (1), and after stirring uniformly, centrifuging, washing and freeze-drying, obtaining β-tricalcium phosphate coated with polydopamine labeled as β-TCP-PDA; and

(3) dispersing the β-TCP-PDA obtained in step (2) into Tollens' reagent, then adding glucose and polyvinylpyrrolidone thereto and stirring evenly to obtain a β-TCP bone repair material loaded with nanosilver particles which is labeled as β-TCP-PDA-Ag, and thereby obtaining the bone repair material.