US 11,890,384 B2
Chitosan superfine fiber systems
Brian Clare, Portland, OR (US); Radim Dvorák, Popůvky (CZ); Simon McCarthy, Portland, OR (US); and Jiri Machát, Brno (CZ)
Assigned to Tricol Biomedical, Inc., Portland, OR (US)
Filed by Tricol Biomedical, Inc., Portland, OR (US)
Filed on Feb. 13, 2017, as Appl. No. 15/431,168.
Claims priority of provisional application 62/294,994, filed on Feb. 12, 2016.
Prior Publication US 2017/0232134 A1, Aug. 17, 2017
Int. Cl. A61L 15/28 (2006.01); A61L 15/42 (2006.01); D01D 5/18 (2006.01); A61L 27/50 (2006.01); A61L 27/56 (2006.01); A61L 24/08 (2006.01); A61L 27/20 (2006.01); A61L 24/00 (2006.01); D01F 9/00 (2006.01); D01D 5/08 (2006.01); D01D 5/084 (2006.01); D01F 1/02 (2006.01); D01D 10/02 (2006.01); D01D 1/02 (2006.01)
CPC A61L 15/28 (2013.01) [A61L 15/425 (2013.01); A61L 24/0036 (2013.01); A61L 24/08 (2013.01); A61L 27/20 (2013.01); A61L 27/50 (2013.01); A61L 27/56 (2013.01); D01D 5/08 (2013.01); D01D 5/084 (2013.01); D01D 5/18 (2013.01); D01F 9/00 (2013.01); A61L 2400/04 (2013.01); A61L 2430/00 (2013.01); D01D 1/02 (2013.01); D01D 10/02 (2013.01); D01F 1/02 (2013.01)] 24 Claims
 
1. A bioactive composition comprising:
at least ten to fifty layers of non-woven chitosan-based fibers having a mean interconnected pore size between 1.5 to about 40 microns, wherein the non-woven chitosan-based fibers in at least one of the layers consist of a combination of:
(a) centrifugally spun chitosan-based fibers with a diameter less than or equal to about 10 microns and greater than 2 microns; and
(b) centrifugally spun chitosan-based fibers having a diameter less than or equal to 2 microns,
wherein the non-woven chitosan-based fibers comprise chitosan consisting of linear polymers of poly-β-(1-4)N-acetyl D-glucosamine comprising at least ten (10) linked monomer units of D-glucosamine and N-acetyl D-glucosamine monomers with β-(1-4) glycosidic linkages, wherein the non-woven chitosan-based fibers in the at least one layer have a mean fiber diameter greater than 0.5 microns, and wherein the non-woven chitosan-based fibers in the at least one layer have a chitosan content of at least about 20% (w/w) and an optional chitosan salt.