CPC A61L 15/28 (2013.01) [A61L 15/425 (2013.01); A61L 24/0036 (2013.01); A61L 24/08 (2013.01); A61L 27/20 (2013.01); A61L 27/50 (2013.01); A61L 27/56 (2013.01); D01D 5/08 (2013.01); D01D 5/084 (2013.01); D01D 5/18 (2013.01); D01F 9/00 (2013.01); A61L 2400/04 (2013.01); A61L 2430/00 (2013.01); D01D 1/02 (2013.01); D01D 10/02 (2013.01); D01F 1/02 (2013.01)] | 24 Claims |
1. A bioactive composition comprising:
at least ten to fifty layers of non-woven chitosan-based fibers having a mean interconnected pore size between 1.5 to about 40 microns, wherein the non-woven chitosan-based fibers in at least one of the layers consist of a combination of:
(a) centrifugally spun chitosan-based fibers with a diameter less than or equal to about 10 microns and greater than 2 microns; and
(b) centrifugally spun chitosan-based fibers having a diameter less than or equal to 2 microns,
wherein the non-woven chitosan-based fibers comprise chitosan consisting of linear polymers of poly-β-(1-4)N-acetyl D-glucosamine comprising at least ten (10) linked monomer units of D-glucosamine and N-acetyl D-glucosamine monomers with β-(1-4) glycosidic linkages, wherein the non-woven chitosan-based fibers in the at least one layer have a mean fiber diameter greater than 0.5 microns, and wherein the non-woven chitosan-based fibers in the at least one layer have a chitosan content of at least about 20% (w/w) and an optional chitosan salt.
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