	US 11,890,383 B2
	Capsules with opacifier
Ljiljana Palangetic, Colmar (FR); Delphine Nombret, Heidolsheim (FR); and Stefaan Jaak Vanquickenborne, Rijmenam (BE)
Assigned to Capsugel Belgium NV, Bornem (BE)
Filed by Capsugel Belgium NV, Bornem (BE)
Filed on Nov. 1, 2022, as Appl. No. 17/978,780.
Application 17/978,780 is a continuation of application No. 17/046,132, granted, now 11,517,535, previously published as PCT/EP2019/062360, filed on May 14, 2019.
Claims priority of application No. 18172133 (EP), filed on May 14, 2018.
Prior Publication US 2023/0090812 A1, Mar. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/48 (2006.01)

CPC A61K 9/4825 (2013.01) [A61K 9/4808 (2013.01); A61K 9/4833 (2013.01)]

18 Claims

1. A hard capsule shell comprising:

a film-forming agent, wherein the film-forming agent is gelatin, or pullulan, or a cellulose based polymer, or any combination thereof; and

an opacifying agent in the form of precipitated calcium carbonate having a median particle diameter D50 of between 0.2 μm and 2.0 μm as measured by laser diffraction, and present in an amount of 3 wt % to 10 wt % based on dry weight of the capsule shell.