US 11,890,375 B2
Ophthalmic solution of difluprednate
Ajay Jaysingh Khopade, Baroda (IN); Arindam Halder, Baroda (IN); and Ankit Shaileshkumar Shah, Baroda (IN)
Assigned to SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED, Mumbai (IN)
Filed by SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED, Mumbai (IN)
Filed on Jul. 28, 2021, as Appl. No. 17/386,935.
Application 17/386,935 is a continuation of application No. 15/768,316, granted, now 11,103,451, previously published as PCT/IN2016/050352, filed on Oct. 15, 2016.
Claims priority of application No. 3932/MUM/2015 (IN), filed on Oct. 16, 2015; and application No. 201621025198 (IN), filed on Jul. 22, 2016.
Prior Publication US 2021/0353540 A1, Nov. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/573 (2006.01); A61K 9/08 (2006.01); A61K 47/18 (2017.01); A61K 47/32 (2006.01); A61K 47/44 (2017.01); A61P 27/02 (2006.01); A61P 27/04 (2006.01); A61K 9/00 (2006.01); A61K 47/02 (2006.01)
CPC A61K 9/08 (2013.01) [A61K 9/0048 (2013.01); A61K 31/573 (2013.01); A61K 47/02 (2013.01); A61K 47/186 (2013.01); A61K 47/32 (2013.01); A61K 47/44 (2013.01); A61P 27/02 (2018.01); A61P 27/04 (2018.01)] 22 Claims
 
1. A clear ophthalmic aqueous solution comprising:
(a) about 0.04% w/v difluprednate;
(b) about 1.4% w/v polyvinyl alcohol or derivative thereof;
(c) about 0.025% w/v benzalkonium chloride; and
(d) about 5.0% w/v polyoxyl 35 castor oil.