CPC A61K 9/0036 (2013.01) [A61K 9/025 (2013.01); A61K 9/06 (2013.01); A61K 31/05 (2013.01); A61K 31/352 (2013.01); A61K 31/455 (2013.01); A61K 47/10 (2013.01); A61K 47/36 (2013.01); A61K 47/44 (2013.01)] | 18 Claims |
1. . A delivery device adapted to mechanically dilate a pelvic anatomical canal of a human subject, the device comprising a composition comprising:
(a) a naturally occurring polysaccharide in an amount ranging from about 1% to about 5% by weight of the composition including low acyl gellan gum in an amount of at least 1% by weight of the composition;
(b) water in an amount of about 60% to about 88% by weight of the composition;
(c) a surfactant in an amount ranging from 0% to about 5% by weight of the composition;
(d) oil in an amount ranging from 0% to about 40% by weight of the composition;
(e) a pH modifying agent;
(f) a cross-linking agent; and
(g) a hydrophilic agent and/or a hydrophobic agent, each of the hydrophilic agent and/or the hydrophobic agent having a beneficial or therapeutic effect in the pelvic anatomical canal,
wherein the composition is formulated as a solid hydrogel in a shape of a cone having a first diameter and a second diameter the first diameter being larger than the second diameter, a length of about 120 mm to about 170 mm, a Young's modulus of about 100 KPa to about 1 MPa, and wherein the pH of the solid hydrogel ranges from about 3.5 to about 5.
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