US 11,890,373 B2
Intravaginal device and uses thereof
Rebecca Sternberg, Tel Aviv (IL); Vered Italiano, Kfar Ben Non (IL); and Varda Messer, Tel Aviv (IL)
Assigned to AQUAFIT INTIMATE LTD., Tel Aviv-Jaffa (IL)
Appl. No. 16/979,354
Filed by AQUAFIT INTIMATE LTD., Tel Aviv—Yafo (IL)
PCT Filed Mar. 11, 2019, PCT No. PCT/IL2019/050265
§ 371(c)(1), (2) Date Sep. 9, 2020,
PCT Pub. No. WO2019/175864, PCT Pub. Date Sep. 19, 2019.
Claims priority of application No. 258017 (IL), filed on Mar. 11, 2018.
Prior Publication US 2021/0000742 A1, Jan. 7, 2021
Int. Cl. A61K 9/02 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/05 (2006.01); A61K 31/352 (2006.01); A61K 31/455 (2006.01); A61K 47/10 (2017.01); A61K 47/36 (2006.01); A61K 47/44 (2017.01)
CPC A61K 9/0036 (2013.01) [A61K 9/025 (2013.01); A61K 9/06 (2013.01); A61K 31/05 (2013.01); A61K 31/352 (2013.01); A61K 31/455 (2013.01); A61K 47/10 (2013.01); A61K 47/36 (2013.01); A61K 47/44 (2013.01)] 18 Claims
 
1. . A delivery device adapted to mechanically dilate a pelvic anatomical canal of a human subject, the device comprising a composition comprising:
(a) a naturally occurring polysaccharide in an amount ranging from about 1% to about 5% by weight of the composition including low acyl gellan gum in an amount of at least 1% by weight of the composition;
(b) water in an amount of about 60% to about 88% by weight of the composition;
(c) a surfactant in an amount ranging from 0% to about 5% by weight of the composition;
(d) oil in an amount ranging from 0% to about 40% by weight of the composition;
(e) a pH modifying agent;
(f) a cross-linking agent; and
(g) a hydrophilic agent and/or a hydrophobic agent, each of the hydrophilic agent and/or the hydrophobic agent having a beneficial or therapeutic effect in the pelvic anatomical canal,
wherein the composition is formulated as a solid hydrogel in a shape of a cone having a first diameter and a second diameter the first diameter being larger than the second diameter, a length of about 120 mm to about 170 mm, a Young's modulus of about 100 KPa to about 1 MPa, and wherein the pH of the solid hydrogel ranges from about 3.5 to about 5.