US 11,890,372 B2
Transfusion preparation
Seiji Tani, Naruto (JP); Seiji Fujita, Naruto (JP); Teru Nakai, Naruto (JP); Yasuhiro Kiuchi, Naruto (JP); Miyuki Yamanaka, Naruto (JP); Yui Hayashi, Naruto (JP); Hiroshi Kanno, Naruto (JP); and Yu Saruwatari, Naruto (JP)
Assigned to OTSUKA PHARMACEUTICAL FACTORY, INC., Naruto (JP)
Appl. No. 16/980,201
Filed by OTSUKA PHARMACEUTICAL FACTORY, INC., Naruto (JP)
PCT Filed Mar. 13, 2019, PCT No. PCT/JP2019/010195
§ 371(c)(1), (2) Date Sep. 11, 2020,
PCT Pub. No. WO2019/176996, PCT Pub. Date Sep. 19, 2019.
Claims priority of application No. 2018-045822 (JP), filed on Mar. 13, 2018.
Prior Publication US 2021/0007975 A1, Jan. 14, 2021
Int. Cl. A61K 9/00 (2006.01); A23L 33/175 (2016.01); A23L 33/115 (2016.01); A23L 33/16 (2016.01); A61J 1/20 (2006.01); A61K 9/107 (2006.01); A61K 35/57 (2015.01); A61K 36/48 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); A61K 47/20 (2006.01); A61K 47/22 (2006.01)
CPC A61K 9/0029 (2013.01) [A23L 33/115 (2016.08); A23L 33/16 (2016.08); A23L 33/175 (2016.08); A61J 1/2093 (2013.01); A61K 9/107 (2013.01); A61K 35/57 (2013.01); A61K 36/48 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A23V 2002/00 (2013.01)] 6 Claims
 
1. An infusion preparation comprising two chambers separated by a communicably openable partition,
a first chamber containing a first-chamber infusion comprising a fat emulsion and further comprising at least one member selected from the group consisting of amino acids that have a buffer action, divalent organic acids, and trivalent organic acids,
a second chamber containing a second-chamber infusion comprising an amino acid and at least calcium as an electrolyte, wherein
a total concentration of the amino acids that have a buffer action, divalent organic acids, and trivalent organic acids in the first-chamber infusion is 0.15 to 0.5 g/L, and
a mixture of the first- and second-chamber infusions has a pH of 6.53 or less as measured 48 hours after the partition is communicably opened.