US 11,890,370 B2
Ultrasound-induced drug delivery system using drug carrier comprising nanobubbles and drug
Myoung Hwan Park, Gyeonggi-do (KR)
Assigned to SAHMYOOK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Seoul (KR); and N TO B CO., LTD., Seoul (KR)
Appl. No. 17/049,468
Filed by SAHMYOOK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Seoul (KR); and N to B Co., Ltd, Seoul (KR)
PCT Filed Sep. 20, 2019, PCT No. PCT/KR2019/012217
§ 371(c)(1), (2) Date Oct. 21, 2020,
PCT Pub. No. WO2020/060275, PCT Pub. Date Mar. 26, 2020.
Claims priority of application No. 10-2018-0113896 (KR), filed on Sep. 21, 2018.
Prior Publication US 2021/0259953 A1, Aug. 26, 2021
Int. Cl. A61K 9/00 (2006.01); A61K 8/06 (2006.01); A61K 8/11 (2006.01); A61K 9/107 (2006.01); A61K 9/51 (2006.01); A61K 45/06 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 9/0009 (2013.01) [A61K 8/06 (2013.01); A61K 8/11 (2013.01); A61K 9/107 (2013.01); A61K 9/5192 (2013.01); A61K 45/06 (2013.01); A61K 2800/10 (2013.01); A61K 2800/413 (2013.01); B82Y 5/00 (2013.01)] 6 Claims
 
1. A method for preparing a drug delivery system in the form of microcapsules in which both a drug and nanobubbles are microencapsulated, the method comprising the steps of:
(a) dissolving the drug in an organic solvent, and then mixing it with an oil to prepare a mixed solution;
(b) removing the organic solvent from the mixed solution;
(c) preparing an oil solution containing both the drug and the nanobubbles, by generating the nanobubbles in the mixed solution from which the organic solvent has been removed; and
(d) mixing the oil solution in an aqueous solution containing a surfactant,
wherein the drug delivery system in the form of the microcapsules is prepared by encapsulating the drug together with the nanobubbles, both being contained in the oil,
wherein the drug is a fat-soluble drug, and
wherein the organic solvent is completely removed from the mixed solution using a vacuum or rotary concentrator.