US 11,890,361 B2
Oral care composition comprising cannabinoids
George Anastassov, New York, NY (US); and Lekhram Changoer, Ridderkerk (NL)
Assigned to APIRx Pharmaceutical USA, LLC, New York, NY (US)
Filed by APIRX Pharmaceutical USA, LLC, New York, NY (US)
Filed on Jul. 2, 2020, as Appl. No. 16/920,065.
Application 16/920,065 is a continuation of application No. 16/184,747, filed on Nov. 8, 2018, abandoned.
Application 16/184,747 is a continuation of application No. 14/970,322, filed on Dec. 15, 2015, granted, now 10,172,786, issued on Jan. 8, 2019.
Claims priority of provisional application 62/092,609, filed on Dec. 16, 2014.
Prior Publication US 2020/0330339 A1, Oct. 22, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/37 (2006.01); A61K 8/92 (2006.01); A61K 8/34 (2006.01); A61K 8/49 (2006.01); A61K 8/35 (2006.01); A61Q 11/00 (2006.01); A61K 8/19 (2006.01); A61K 8/86 (2006.01); A61K 8/25 (2006.01); A61K 8/44 (2006.01); A61K 8/46 (2006.01); A61K 8/73 (2006.01); A61K 31/352 (2006.01); A61K 8/9717 (2017.01); A61K 8/9789 (2017.01)
CPC A61K 8/19 (2013.01) [A61K 8/25 (2013.01); A61K 8/345 (2013.01); A61K 8/442 (2013.01); A61K 8/463 (2013.01); A61K 8/731 (2013.01); A61K 8/86 (2013.01); A61K 8/9717 (2017.08); A61K 8/9789 (2017.08); A61K 31/352 (2013.01); A61Q 11/00 (2013.01); A61K 2800/28 (2013.01)] 21 Claims
 
1. A cannabinoid toothpaste composition comprising:
(a) at least one abrasive agent selected from the group consisting of abrasive silica, hydrated alumina, water-insoluble sodium metaphosphate, tricalcium phosphate, calcium phosphate dihydrate, anhydrous dicalcium phosphate, calcium pyrophosphate, calcium carbonate, sodium bicarbonate, and aluminum silicate;
(b) at least one binder selected from the group consisting of guar gum, xanthan gum, sodium alginate, karaya gum, bentonite, carrageenan, blanose cellulose gum, and methylcellulose;
(c) at least one humectant selected from the group consisting of sorbitol solution, glycerin solution, and propylene glycol;
(d) at least one fluoridating agent selected from the group consisting of sodium fluoride, potassium fluoride, calcium fluoride, sodium fluorosilicate, acidulated phosphate fluoride, difluorosilane, sodium monofluorophosphate, ammonium fluorosilicate, and stannous fluoride;
(e) at least one surfactant selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfoacetate, dioctyl sodium sulfosuccinate, sulfolaurate, sodium lauryl sarcosinate, sodium stearyl fumarate, and sodium stearyl lactate;
(f) water;
(g) a silicon dioxide-based thickener;
(h) lactoferrin; and
(i) one or more cannabinoids selected from the group consisting of Δ9-tetrahydrocannabinol, cannabidiol, and cannabigerol, wherein the one or more cannabinoids is present in an amount of 0.1 to 0.5 weight percent, and wherein lactoferrin is present in an amount of 0.1 to 0.5 weight percent.