CPC A61K 47/6851 (2017.08) [A61K 47/549 (2017.08); A61K 47/6803 (2017.08); A61K 49/0043 (2013.01); A61K 49/0058 (2013.01); A61K 51/1045 (2013.01); C07D 209/20 (2013.01); C07H 21/00 (2013.01); C07K 16/32 (2013.01); C07K 2317/24 (2013.01); C07K 2317/55 (2013.01)] | 19 Claims |
1. A chemoselectively modified biomolecular conjugate comprising a protein, polypeptide or a peptide comprising naturally-occurring amino acids and one, or more, non-naturally-occurring amino acids comprising a surface-exposed 5-hydroxytryptophan or a 5-aminotryptophan moiety incorporated into the protein, polypeptide or peptide, wherein the non-naturally-occurring amino acid comprising the 5-hydroxytryptophan or the 5-aminotryptophan is chemoselectively modified over the naturally-occurring amino acids of the biomolecule, wherein the 5-hydroxytryptophan or the 5-aminotroptophan is covalently coupled to an aryl-diazonium compound selected from the group consisting of: 4-nitorbenzenediazonium (4NDz); 4-carboxybenzenediazonium (4NCDz) or 4-methoxvhenzenediazonium (4MCDz).
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