US 11,890,342 B2
Stimulus-responsive micellar carrier
Dylan J. Boday, Tucson, AZ (US); Jeannette M. Garcia, San Leandro, CA (US); James L. Hedrick, Pleasanton, CA (US); Nathaniel Park, San Jose, CA (US); Rudy J. Wojtecki, San Jose, CA (US); Yang Chuan, The Nanos (SG); Ashlynn Lee, The Nanos (SG); Zhen Chang Liang, The Nanos (SG); Shaoqiong Liu, The Nanos (SG); and Yi Yan Yang, The Nanos (SG)
Assigned to International Business Machines Corporation, Armonk, NY (US)
Filed by International Business Machines Corporation, Armonk, NY (US); and Agency for Science, Technology, and Research (ASTAR), Singapore (SG)
Filed on Dec. 22, 2020, as Appl. No. 17/130,415.
Application 17/130,415 is a division of application No. 15/479,071, filed on Apr. 4, 2017, granted, now 11,045,552.
Prior Publication US 2021/0145970 A1, May 20, 2021
Int. Cl. A61K 47/34 (2017.01); A61K 9/00 (2006.01); A61K 9/107 (2006.01); A61K 38/00 (2006.01); A61K 31/7088 (2006.01); C08G 64/18 (2006.01); A61K 47/10 (2017.01)
CPC A61K 47/34 (2013.01) [A61K 9/0019 (2013.01); A61K 9/107 (2013.01); A61K 31/7088 (2013.01); A61K 38/00 (2013.01); A61K 47/10 (2013.01); C08G 64/183 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for producing a linear block copolymer, comprising:
preparing an alcohol terminated polyethylene glycol (PEG) material having an acetal group, the preparation comprising:
reacting an alcohol terminated PEG with 2-(vinyloxy)ethyl acetate to form an acetate terminated PEG having the acetal group, and
hydrolyzing the acetate terminated PEG having the acetal group to form the alcohol terminated PEG material having the acetal group;
introducing the alcohol terminated PEG having the acetal group with a cyclic carbonate monomer; and
mixing the alcohol terminated PEG having the acetal group, the cyclic carbonate monomer, and a base to form a linear block copolymer, wherein the linear block copolymer consists of a hydrophilic block comprising a polyethylene glycol, a hydrophobic block having a structure comprising a carbonate group, and a stimulus-responsive junction moiety having the structure

OG Complex Work Unit Chemistry
wherein one wavy bond represents a bond to the polyethylene glycol of the hydrophilic block and the other wavy bond represents a bond to the carbonate group of the hydrophobic block.