CPC A61K 36/185 (2013.01) [A61K 9/006 (2013.01); A61K 9/7023 (2013.01); A61K 31/00 (2013.01); A61K 31/05 (2013.01); A61K 31/352 (2013.01); B01D 11/0407 (2013.01); A61K 2236/00 (2013.01)] | 26 Claims |
1. A process for obtaining a first extract of Cannabis sativa, Cannabis indica, or combination thereof, enriched with at least one of: cannabinol; cannabinolic acid;
Δ(9)-tetrahydrocannabinolic acid; Δ(9)-cannabidiol; Δ(9)-tetrahydrocannabidiolic acid;
Δ(8)-tetrahydrocannabinolic acid; Δ(8)-tetrahydrocannabidiol; Δ(8)-tetrahydrocannabidiolic acid; Δ(9)-tetrahydrocannabivarin; cannabigerol; cannabigerolic acid; cannabichromene; cannabichromenic acid; cannabicyclol; and cannabicyclolic acid, and
a second extract of Cannabis sativa, Cannabis indica, or combination thereof, enriched with at least one of Δ(8)-tetrahydrocannabinol and Δ(9)-tetrahydrocannabinol, the process comprising:
(a) contacting Cannabis sativa, Cannabis indica, or a combination thereof, with carbon dioxide as the sole supercritical fluid solvent, at a pressure of 1,400 psi to 3,800 psi, at a temperature of 35° C. to 65° C., for a period of time of 1.5 hours to 8.5 hours, to provide an enriched extract of Cannabis sativa, Cannabis indica, or combination thereof; and
(b) removing the supercritical carbon dioxide from the extract; wherein the (a) contacting of the Cannabis sativa, Cannabis indica, or a combination thereof, with the supercritical carbon dioxide and then the (b) removing the supercritical carbon dioxide, is carried out two or more times, such that the process is a supercritical carbon dioxide fluid extraction;
wherein a first supercritical carbon dioxide fluid extraction is carried out such that:
(i) the contacting of the Cannabis sativa, Cannabis indica, or a combination thereof, with the supercritical carbon dioxide, is carried out at a pressure of 1,600 psi to 2,000 psi, at a temperature of 44° C. to 54° C., for a period of time of 1.5 hours to 4.5 hours, to provide the first extract;
wherein a second supercritical carbon dioxide fluid extraction is carried out such that:
(i) the contacting of the Cannabis sativa, Cannabis indica, or a combination thereof, with the supercritical carbon dioxide, is carried out at a pressure of 2,250 psi to 3,800 psi, at a temperature of 44° C. to 54° C., for a period of time of 3.5 hours to 8.5 hours, to provide a second extract.
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