CPC A61K 31/7048 (2013.01) [A61K 9/0065 (2013.01); A61K 31/43 (2013.01); A61K 31/4439 (2013.01); A61K 47/46 (2013.01); A61P 31/04 (2018.01)] | 4 Claims |
1. An orally administered pharmaceutical composition for eradicating clarithromycin-resistant Helicobacter pylori, comprising a β-lactam antibiotic, and a gastric acid inhibitor, and a complex of a non-absorbable antibiotic with clay mineral,
wherein the non-absorbable antibiotic is selected from the group consisting of gentamicin and netilmicin at an effective amount that eradicates the clarithromycin-resistant Helicobacter pylori and decreases damage of the surface epithelium, inflammatory cell infiltration, and/or submucosal edema, and
wherein the clay mineral is selected from the group consisting of montmorillonite, bentonite, beidellite, nontronite, saponite, and hectorite.
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