US 11,890,295 B2
Helicobacter pylori eradication method including step for orally administering composition including complex of non-absorbable antibiotic and clay mineral to subject
Jae-Hwan Kim, Pohang-si (KR); Il-Mo Kang, Seoul (KR); Young-Goo Song, Seoul (KR); Ki-Min Roh, Daejeon (KR); Yun-Goo Song, Seoul (KR); Sung-Man Seo, Pohang-si (KR); and Dae-Young Kim, Geumsan-gun (KR)
Assigned to KOREA INSTITUTE OF GEOSCIENCE AND MINERAL RESOURCES, Daejeon (KR)
Appl. No. 17/269,501
Filed by KOREA INSTITUTE OF GEOSCIENCE AND MINERAL RESOURCES, Daejeon (KR)
PCT Filed Jun. 24, 2019, PCT No. PCT/KR2019/007611
§ 371(c)(1), (2) Date Feb. 18, 2021,
PCT Pub. No. WO2020/045807, PCT Pub. Date Mar. 5, 2020.
Claims priority of application No. 10-2018-0103868 (KR), filed on Aug. 31, 2018; and application No. 10-2019-0073709 (KR), filed on Jun. 20, 2019.
Prior Publication US 2021/0196740 A1, Jul. 1, 2021
Int. Cl. A61K 31/7048 (2006.01); A61P 31/04 (2006.01); A61K 9/00 (2006.01); A61K 31/43 (2006.01); A61K 31/4439 (2006.01); A61K 47/46 (2006.01)
CPC A61K 31/7048 (2013.01) [A61K 9/0065 (2013.01); A61K 31/43 (2013.01); A61K 31/4439 (2013.01); A61K 47/46 (2013.01); A61P 31/04 (2018.01)] 4 Claims
 
1. An orally administered pharmaceutical composition for eradicating clarithromycin-resistant Helicobacter pylori, comprising a β-lactam antibiotic, and a gastric acid inhibitor, and a complex of a non-absorbable antibiotic with clay mineral,
wherein the non-absorbable antibiotic is selected from the group consisting of gentamicin and netilmicin at an effective amount that eradicates the clarithromycin-resistant Helicobacter pylori and decreases damage of the surface epithelium, inflammatory cell infiltration, and/or submucosal edema, and
wherein the clay mineral is selected from the group consisting of montmorillonite, bentonite, beidellite, nontronite, saponite, and hectorite.