US 11,890,275 B2
Therapeutic compounds
Lynnie Trzoss, San Diego, CA (US); Juan Manuel Betancort, San Diego, CA (US); Toufike Kanouni, Rancho Sante Fe, CA (US); Michael Brennan Wallace, San Diego, CA (US); and Amogh Boloor, San Diego, CA (US)
Assigned to Celgene Quanticel Research, Inc.
Filed by CELGENE QUANTICEL RESEARCH, INC., San Diego, CA (US)
Filed on Mar. 15, 2021, as Appl. No. 17/201,190.
Application 17/201,190 is a division of application No. 16/773,143, filed on Jan. 27, 2020, granted, now 11,020,380.
Application 16/773,143 is a continuation of application No. 15/956,434, filed on Apr. 18, 2018, granted, now 10,617,680, issued on Apr. 14, 2020.
Claims priority of provisional application 62/486,894, filed on Apr. 18, 2017.
Claims priority of provisional application 62/657,456, filed on Apr. 13, 2018.
Prior Publication US 2021/0205284 A1, Jul. 8, 2021
Int. Cl. C07D 413/04 (2006.01); A61K 31/4412 (2006.01); A61P 37/00 (2006.01); A61P 35/00 (2006.01); A61P 29/00 (2006.01)
CPC A61K 31/4412 (2013.01) [A61P 29/00 (2018.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01)] 44 Claims
 
1. A compound having the structure of Formula I:

OG Complex Work Unit Chemistry
wherein a compound of Formula I includes a pharmaceutically acceptable salt thereof, and
wherein
X6 is CR7, wherein R7 is hydrogen, or alkyl;
R2 is CH3;
R5 is halogen, —N(R22)2, —NH(R22), —OW, —SW, or optionally substituted alkyl, aryl, aralkyl, cycloalkyl, or cycloalkylalkyl, wherein
W is optionally substituted alkyl, aryl, aralkyl, cycloalkyl, heterocyclyl, or heteroarylalkyl;
R6 is methyl;
RA is

OG Complex Work Unit Chemistry
wherein X is a bond, CH2, CHR, or CRR′; wherein
R and R′ are independently halogen, halide, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, —SO2R21, or —N(R22)SO2R21; wherein
each R21 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl;
each R22 is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and
R1 is hydrogen or optionally substituted alkyl, aryl, aralkyl, alkoxy, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl.