CPC A61K 31/4412 (2013.01) [A61P 29/00 (2018.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01)] | 44 Claims |
1. A compound having the structure of Formula I:
wherein a compound of Formula I includes a pharmaceutically acceptable salt thereof, and
wherein
X6 is CR7, wherein R7 is hydrogen, or alkyl;
R2 is CH3;
R5 is halogen, —N(R22)2, —NH(R22), —OW, —SW, or optionally substituted alkyl, aryl, aralkyl, cycloalkyl, or cycloalkylalkyl, wherein
W is optionally substituted alkyl, aryl, aralkyl, cycloalkyl, heterocyclyl, or heteroarylalkyl;
R6 is methyl;
RA is
wherein X is a bond, CH2, CHR, or CRR′; wherein
R and R′ are independently halogen, halide, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, —SO2R21, or —N(R22)SO2R21; wherein
each R21 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl;
each R22 is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and
R1 is hydrogen or optionally substituted alkyl, aryl, aralkyl, alkoxy, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl.
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