US 11,890,116 B2
Systems and methods for detecting worsening heart failure
Pramodsingh Hirasingh Thakur, Woodbury, MN (US); Yi Zhang, Plymouth, MN (US); Qi An, Shoreview, MN (US); and Viktoria A. Averina, Shoreview, MN (US)
Assigned to Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed by Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed on Nov. 28, 2022, as Appl. No. 17/994,934.
Application 17/994,934 is a continuation of application No. 16/853,421, filed on Apr. 20, 2020, granted, now 11,523,778.
Application 16/853,421 is a continuation of application No. 15/473,783, filed on Mar. 30, 2017, granted, now 10,660,577.
Claims priority of provisional application 62/316,905, filed on Apr. 1, 2016.
Prior Publication US 2023/0098070 A1, Mar. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/091 (2006.01); G16H 40/63 (2018.01); G16H 50/30 (2018.01); G16H 50/20 (2018.01); G16H 40/67 (2018.01); A61B 5/0205 (2006.01); A61N 1/362 (2006.01); A61N 1/365 (2006.01); A61B 5/08 (2006.01); A61B 7/04 (2006.01)
CPC A61B 5/7275 (2013.01) [A61B 5/0205 (2013.01); A61B 5/091 (2013.01); A61B 5/4836 (2013.01); A61B 5/686 (2013.01); A61B 5/7264 (2013.01); A61B 5/7282 (2013.01); A61B 5/746 (2013.01); A61N 1/3627 (2013.01); A61N 1/36585 (2013.01); G16H 40/63 (2018.01); G16H 40/67 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); A61B 5/0816 (2013.01); A61B 7/04 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for predicting a disease status of a patient, the system comprising:
a detector circuit configured to be coupled to an ambulatory medical device implanted in or associated with the patient, where the detector circuit is further configured to:
receive physiological information of the patient from a physiologic sensor of the ambulatory medical device;
receive a risk indication indicating a clinical risk of the patient developing the disease status in a future time;
generate a first detection indication using a first signal metric,
and generate a second detection indication using a second signal metric,
the first and second signal metrics different from each other and associated with the received physiological information;
compute a composite score using a weighted combination of the first detection indication and the second detection indication each scaled by respective weight factors,
the respective weight factors determined based on the received risk indication;
and generate a composite prediction of the disease status based on a comparison of the composite score to a prediction threshold or a score range;
and an output circuit configured to generate an alert about the composite prediction of the disease status and present on a user interface the generated alert and the composite prediction of the disease status to a user or a patient management process of the system,
where the alert includes a display of the composite prediction and one or more of: the first signal metric, the second signal metric, the first detection indication, and the second detection indication.