US 11,890,112 B2
Skull-mounted drug and pressure sensor
Yehoshua Shachar, Santa Monica, CA (US); Thomas Chen, La Canada, CA (US); Thomas J. Lobl, Valencia, CA (US); Jeffrey A. Brydle, Pasadena, CA (US); Juan R. Gonzalez, Arleta, CA (US); Virote Indravudh, Santa Clarita, CA (US); Christian Merot, Ventura, CA (US); Allan R. Schwartz, Thousand Oaks, CA (US); and Chad Srisathapat, Sun Valley, CA (US)
Assigned to Cognos Therapeutics Inc., Inglewood, CA (US)
Filed by Cognos Therapeutics Inc., Los Angeles, CA (US)
Filed on Mar. 6, 2020, as Appl. No. 16/811,948.
Application 16/811,948 is a division of application No. 15/594,251, filed on May 12, 2017, granted, now 10,786,155.
Claims priority of provisional application 62/336,446, filed on May 13, 2016.
Prior Publication US 2020/0214567 A1, Jul. 9, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/1459 (2006.01); A61B 5/03 (2006.01); A61M 5/142 (2006.01); A61M 27/00 (2006.01); A61M 5/14 (2006.01); A61B 5/01 (2006.01); A61M 1/00 (2006.01); A61B 90/00 (2016.01)
CPC A61B 5/6868 (2013.01) [A61B 5/0031 (2013.01); A61B 5/03 (2013.01); A61B 5/031 (2013.01); A61B 5/1459 (2013.01); A61B 5/4839 (2013.01); A61M 5/142 (2013.01); A61B 5/01 (2013.01); A61B 2090/064 (2016.02); A61B 2562/0233 (2013.01); A61M 1/60 (2021.05); A61M 5/14 (2013.01); A61M 27/006 (2013.01)] 3 Claims
OG exemplary drawing
 
1. An apparatus for use with an exterior source of a drug and an exterior monitor comprising:
a ventricular catheter with a CSF optical sensing chamber and drug delivery port; and
an implantable stand-alone skull-mounted drug and pressure sensor (SPS) comprising:
a vascular access port (VAP) communicated with the ventricular catheter through which the drug may be provided from the exterior source;
an LED bundle coupled to the ventricular catheter, the LED bundle comprising a plurality of LEDs which are each configured to measure at least one optical absorption profile of cerebrospinal fluid (CSF);
a photodetector coupled to the ventricular catheter;
a pressure sensor communicated to the ventricular catheter for measuring CSF pressure;
a first microcontroller subsystem for bidirectionally communicating with the exterior monitor, the microcontroller subsystem communicated to the pressure sensor;
a second microcontroller subsystem for controlling the LED bundle and photodetector, wherein the second microcontroller subsystem communicates a measurement detected by the photodetector to the first microcontroller subsystem;
a Bluetooth radio communicated to the first microcontroller subsystem for communicating with the exterior monitor;
an antenna coupled to the Bluetooth radio; and
a power source coupled to the pressure sensor, the first microcontroller subsystem, and the Bluetooth radio,
where the CSF optical sensing chamber is configured to receive light from the LED bundle and reflect it back to the photodetector.