US 11,890,111 B2
Skull-mounted drug and pressure sensor
Yehoshua Shachar, Santa Monica, CA (US); Thomas Chen, La Canada, CA (US); Thomas J. Lobl, Valencia, CA (US); Jeffrey A. Brydle, Pasadena, CA (US); Juan R. Gonzalez, Arleta, CA (US); Virote Indravudh, Santa Clarita, CA (US); Christian Merot, Ventura, CA (US); Allan R. Schwartz, Thousand Oaks, CA (US); and Chad Srisathapat, Sun Valley, CA (US)
Assigned to Cognos Therapeutics Inc., Inglewood, CA (US)
Filed by Cognos Therapeutics Inc., Los Angeles, CA (US)
Filed on Mar. 6, 2020, as Appl. No. 16/811,890.
Application 16/811,890 is a division of application No. 15/594,251, filed on May 12, 2017, granted, now 10,786,155.
Claims priority of provisional application 62/336,446, filed on May 13, 2016.
Prior Publication US 2020/0205663 A1, Jul. 2, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/1459 (2006.01); A61B 5/03 (2006.01); A61M 5/142 (2006.01); A61M 27/00 (2006.01); A61M 5/14 (2006.01); A61B 5/01 (2006.01); A61M 1/00 (2006.01); A61B 90/00 (2016.01)
CPC A61B 5/6868 (2013.01) [A61B 5/0031 (2013.01); A61B 5/03 (2013.01); A61B 5/031 (2013.01); A61B 5/1459 (2013.01); A61B 5/4839 (2013.01); A61M 5/142 (2013.01); A61B 5/01 (2013.01); A61B 2090/064 (2016.02); A61B 2562/0233 (2013.01); A61M 1/60 (2021.05); A61M 5/14 (2013.01); A61M 27/006 (2013.01)] 5 Claims
OG exemplary drawing
 
1. An apparatus for use with an exterior source of a drug and an exterior monitor comprising:
an implantable skull-mounted drug and pressure sensor (SOS);
an implantable power and communication unit (PCU) electrically coupled to the SOS; and
a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS,
where the PCU includes a ventricular access port through which a drug may be provided from the exterior source, and a first microcontroller subsystem for bidirectionally communicating with the first pressure sensor and the exterior monitor, and
where the SOS comprises:
an optical ventricular catheter comprising a CSF optical sensing chamber and a drug delivery port;
an LED bundle coupled to the optical ventricular catheter, the LED bundle comprising a plurality of LEDs which are each configured to measure at least one optical absorption profile of cerebrospinal fluid (CSF);
a photodetector coupled to the optical ventricular catheter; and
a second microcontroller subsystem for controlling the LED bundle and photodetector, wherein the second microcontroller subsystem communicates a measurement detected by the photodetector to the first microcontroller subsystem,
where the CSF optical sensing chamber is configured to receive light from the LED bundle and reflect it back to the photodetector.