US 10,557,854 B2
CA IX—NIR dyes and their uses
Sumith A Kularatne, West Lafayette, IN (US); Pravin Gagare, West Lafayette, IN (US); and Ananda Kumar Kanduluru, West Lafayette, IN (US)
Assigned to On Target Laboratories, LLC, West Lafayette, IN (US)
Filed by On Target Laboratories, LLC, West Lafayette, IN (US)
Filed on Mar. 16, 2017, as Appl. No. 15/461,361.
Claims priority of provisional application 62/309,412, filed on Mar. 16, 2016.
Prior Publication US 2017/0285040 A1, Oct. 5, 2017
Int. Cl. A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61B 10/00 (2006.01); G01N 33/58 (2006.01); A61B 1/00 (2006.01); A61B 1/04 (2006.01); C09B 23/16 (2006.01); G01N 33/573 (2006.01); G01N 33/574 (2006.01); A61K 49/00 (2006.01); A61B 90/20 (2016.01); A61B 90/50 (2016.01)
CPC G01N 33/583 (2013.01) [A61B 1/00009 (2013.01); A61B 1/043 (2013.01); A61B 5/0071 (2013.01); A61B 5/0073 (2013.01); A61B 5/0084 (2013.01); A61B 5/7282 (2013.01); C09B 23/166 (2013.01); C12Y 402/01001 (2013.01); G01N 33/573 (2013.01); G01N 33/574 (2013.01); A61B 90/20 (2016.02); A61B 2090/502 (2016.02); A61B 2560/0431 (2013.01); A61K 49/0017 (2013.01); G01N 2333/988 (2013.01)] 50 Claims
 
1. A compound having the formula:
B-W-X-Y-Z
wherein B is a CA IX-targeted molecule is selected from the group consisting of

OG Complex Work Unit Drawing

OG Complex Work Unit Drawing

OG Complex Work Unit Drawing

OG Complex Work Unit Drawing

OG Complex Work Unit Drawing
wherein n is 0, 1, 2, 3 . . . ; m is 0, 1, 2, 3, 4, 5, . . . and p is 0, 1, 2, 3, . . . ;
W is an extended hydrophobic residue;
X is a hydrophobic spacer;
Y is an amino acid spacer; and
Z is a NIR dye.