US 11,869,631 B2
Cross-variant polygenic predictive data analysis
Kenneth Bryan, County Dublin (IE); Megan O'Brien, Kildare (IE); David S. Monaghan, County Dublin (IE); and Chirag Chadha, Dublin (IE)
Assigned to Optum Services (Ireland) Limited, Dublin (IE)
Filed by Optum Services (Ireland) Limited, Dublin (IE)
Filed on Sep. 8, 2022, as Appl. No. 17/930,438.
Application 17/930,438 is a continuation of application No. 16/863,362, filed on Apr. 30, 2020, granted, now 11,482,302.
Prior Publication US 2023/0031174 A1, Feb. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G16B 30/00 (2019.01); G16B 20/40 (2019.01); G16B 10/00 (2019.01); G06N 20/00 (2019.01); G16H 50/30 (2018.01); G06F 18/21 (2023.01); G06F 18/2113 (2023.01)
CPC G16B 20/40 (2019.02) [G06F 18/217 (2023.01); G06F 18/2113 (2023.01); G06N 20/00 (2019.01); G16B 10/00 (2019.02); G16B 30/00 (2019.02); G16H 50/30 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A computer-implemented method comprising:
generating, by one or more processors and for one or more genetic variants of a plurality of genetic variants that is associated with a chromosome, a per-variant genetic risk score based at least in part on: (i) a per-variant risk probability value for the one or more genetic variants in relation to a target medical condition that is selected from a plurality of per-variant risk probability values for the plurality of genetic variants, and (ii) a per-variant allele count for the one or more genetic variants in relation to a target individual that is selected from a plurality of per-variant allele counts for the plurality of genetic variants;
generating, by the one or more processors, a genetic risk profile for the plurality of genetic variants, wherein: (i) the genetic risk profile comprises one or more per-chromosome profile segments each associated with a respective chromosome of a plurality of chromosomes, and (ii) each per-chromosome profile segment of the one or more per-chromosome profile segments that is associated with the respective chromosome of the plurality of chromosomes comprises each per-variant genetic risk score for a genetic variant in a subset of the plurality of genetic variants that is associated with the respective chromosome; and
initiating, by the one or more processors, the performance of one or more prediction-based actions based at least in part on the genetic risk profile.