US 11,867,684 B2
Sample dispenser including an internal standard and methods of use thereof
Zheng Ouyang, West Lafayette, IN (US); He Wang, West Lafayette, IN (US); Nicholas E. Manicke, West Lafayette, IN (US); Robert Graham Cooks, West Lafayette, IN (US); Qian Yang, West Lafayette, IN (US); and Jiangjiang Liu, West Lafayette, IN (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Filed by Purdue Research Foundation, West Lafayette, IN (US)
Filed on Jan. 25, 2022, as Appl. No. 17/584,100.
Application 17/584,100 is a continuation of application No. 16/936,683, filed on Jul. 23, 2020, granted, now 11,287,414.
Application 16/936,683 is a continuation of application No. 15/357,048, filed on Nov. 21, 2016, granted, now 10,761,083.
Application 15/357,048 is a continuation of application No. 13/784,094, filed on Mar. 4, 2013, granted, now 9,500,572, issued on Nov. 22, 2016.
Application 13/784,094 is a continuation in part of application No. 13/265,110, granted, now 8,859,956, issued on Oct. 14, 2014, previously published as PCT/US2010/032881, filed on Apr. 29, 2010.
Claims priority of provisional application 61/608,944, filed on Mar. 9, 2012.
Claims priority of provisional application 61/308,332, filed on Feb. 26, 2010.
Claims priority of provisional application 61/246,707, filed on Sep. 29, 2009.
Claims priority of provisional application 61/174,215, filed on Apr. 30, 2009.
Prior Publication US 2022/0221442 A1, Jul. 14, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/49 (2006.01); G01N 1/28 (2006.01); H01J 49/06 (2006.01); H01J 49/16 (2006.01); H01J 49/00 (2006.01); G01N 33/487 (2006.01); G01N 1/10 (2006.01)
CPC G01N 33/492 (2013.01) [G01N 1/28 (2013.01); G01N 1/286 (2013.01); G01N 33/48714 (2013.01); G01N 33/48785 (2013.01); G01N 33/491 (2013.01); H01J 49/0009 (2013.01); H01J 49/0027 (2013.01); H01J 49/16 (2013.01); G01N 1/10 (2013.01); G01N 2001/2893 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for analyzing a sample comprising:
preparing a mixture of a sample with a controlled amount of an internal standard;
contacting the mixture to a porous substrate that tapers to at least one tip, wherein the porous material is kept separate from a flow of solvent and the probe operates without pneumatic assistance;
applying a high voltage to the porous material such that an electric field is generated at a tip of the material so as to generate ions of an analyte and ions of the internal standard that are expelled from the porous material; and
analyzing the expelled ions.