CPC C12N 9/16 (2013.01) [A61K 47/68 (2017.08); C07K 14/00 (2013.01); C07K 16/28 (2013.01); C07K 16/2881 (2013.01); C07K 19/00 (2013.01); C12N 9/18 (2013.01); C12N 9/2402 (2013.01); C12N 15/62 (2013.01); C12Y 301/06013 (2013.01); A61K 38/00 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01); C12Y 301/04012 (2013.01); C12Y 302/01045 (2013.01); C12Y 310/01001 (2013.01)] | 35 Claims |
1. A method of treating Hunter syndrome in a subject in need thereof, comprising administering to the subject a protein comprising:
a. a fusion polypeptide comprising a first Fc polypeptide linked to an iduronate 2-sulfatase (IDS) amino acid sequence, wherein the IDS amino acid sequence comprises a sequence having at least 90% identity to SEQ ID NO: 92, and wherein the IDS amino acid sequence is linked to the N-terminus of the first Fc polypeptide; and
b. a second Fc polypeptide comprising a sequence having at least 90% identity to SEQ ID NO: 151 that is capable of specifically binding to a transferrin receptor.
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