US 11,866,695 B2
Methods and systems and related compositions for mixtures separation with a solid matrix
Rustem F. Ismagilov, Altadena, CA (US); Erik Jue, Pasadena, CA (US); and Daan Witters, San Diego, CA (US)
Assigned to CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US)
Filed by CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US)
Filed on Dec. 22, 2020, as Appl. No. 17/131,449.
Claims priority of provisional application 62/953,178, filed on Dec. 23, 2019.
Prior Publication US 2021/0189379 A1, Jun. 24, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/10 (2006.01); C12Q 1/6806 (2018.01)
CPC C12N 15/1006 (2013.01) [C12N 15/1013 (2013.01); C12Q 1/6806 (2013.01)] 15 Claims
 
1. A method to selectively remove a target compound having a water solubility equal to or greater than 0.001 g per 100 mL at 25° C. at 1 atm pressure from a solid matrix further retaining a nucleic acid, the method comprising:
contacting the solid matrix with a target compound removing agent having a water solubility equal to or less than 0.05 g per 100 mL at 25° C. at 1 atm pressure with water having a solubility in the removing agent of less than 10 g per 100 mL at 25° C. at 1 atm pressure, the contacting performed to remove the target compound from the solid matrix.