US 11,866,683 B2
Cell culture apparatuses with manifolds including column structures
Gregory Roger Martin, Acton, ME (US); and Allison Jean Tanner, Portsmouth, NH (US)
Assigned to CORNING INCORPORATED, Corning, NY (US)
Appl. No. 16/758,066
Filed by CORNING INCORPORATED, Corning, NY (US)
PCT Filed Nov. 5, 2018, PCT No. PCT/US2018/059180
§ 371(c)(1), (2) Date Apr. 22, 2020,
PCT Pub. No. WO2019/090211, PCT Pub. Date May 9, 2019.
Claims priority of provisional application 62/582,086, filed on Nov. 6, 2017.
Prior Publication US 2021/0189314 A1, Jun. 24, 2021
Int. Cl. C12M 1/00 (2006.01); C12M 3/00 (2006.01); C12M 1/12 (2006.01)
CPC C12M 23/40 (2013.01) [C12M 23/44 (2013.01); C12M 23/58 (2013.01); C12M 29/20 (2013.01); C12M 37/04 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A cell culture apparatus, comprising:
a cell culture module comprising multiple cell culture chambers;
each cell culture chamber having a top, a bottom and sidewalls, defining an interior space for culturing cells;
wherein each cell culture chamber has at least one inlet in a sidewall of the cell culture chamber through which liquid can flow into and out of the cell culture chamber;
wherein the multiple cell culture chambers are stacked one above the other to form the cell culture module;
a manifold comprising a side wall base structure and a monolithic column;
wherein the manifold is aligned along a side of the cell culture module;
wherein the manifold provides a fluid pathway from a manifold opening to each of the cell culture chambers through cell culture chamber inlets;
wherein the monolithic column is a portion of the manifold and comprises a cross-sectional shape extending along the multiple cell culture chambers;
and wherein the monolithic column provides an enlarged volume inside the manifold to enable fluid to flow through the manifold to the cell culture chamber inlets.