CPC C07K 14/70514 (2013.01) [A61K 38/162 (2013.01); A61K 38/1774 (2013.01); A61K 38/1793 (2013.01); A61P 31/18 (2018.01); C07K 14/005 (2013.01); C07K 14/7158 (2013.01); C07K 19/00 (2013.01); G01N 33/56988 (2013.01); A61K 45/06 (2013.01); C07K 2319/30 (2013.01); C12N 2740/16022 (2013.01); C12N 2740/16033 (2013.01); G01N 2333/16 (2013.01)] | 19 Claims |
1. An antibody derivative comprising from N- to C-terminus:
(a) a human CD4 sequence comprising SEQ ID NO:1 and SEQ ID NO:2 or a sequence having at least 96% identity thereto,
(b) the Fc portion of a human IgG,
(c) a moiety consisting of a linker polypeptide of sequence (GGGGS)n wherein n=10, and
(d) a gp41-derived polypeptide comprising a sequence selected from the group consisting of SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 and SEQ ID NO:10 or a sequence having at least 96% identity thereto.
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