CPC C07K 14/605 (2013.01) [A61K 9/0053 (2013.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); A61K 38/00 (2013.01)] | 7 Claims |
1. A Glucagon-like Peptide-1 (GLP-1) agonist peptide or salt thereof comprising a modification, wherein the modification is a group of formula (I) attached to an amino acid residue in the peptide
wherein
U represents —C(O)—CH2—O—(CH2)2—O—(CH2)2—NH—} wherein } is point of attachment to W;
W represents
—C(O)—NH—(CH2)3-4—NH—],
—C(O)—C(CH3)2—NH—], or
wherein ] is point of attachment to Y;
Y represents —C(O)—(CH2)2—CH(COOH)NH— and — is point of attachment to Z;
Z represents —C(O)—(CH2)n—COOH or —C(O)—(CH2)n—CH3 wherein n is an integer from 14-20.
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