US 11,866,477 B2
GLP-1 analogues
Rajamannar Thennati, Gujarat (IN); Nishith Chaturvedi, Gujarat (IN); Vinod Sampatrao Burade, Gujarat (IN); Pradeep Dinesh Shahi, Gujarat (IN); Muthukumaran Natarajan, Gujarat (IN); Ravishankara Madavati Nagaraja, Gujarat (IN); Rishit Mansukhlal Zalawadia, Gujarat (IN); Vipulkumar Shankarbhai Patel, Gujarat (IN); Kunal Pandya, Gujarat (IN); Brijeshkumar Patel, Gujarat (IN); Dhiren Rameshchandra Joshi, Gujarat (IN); Krunal Harishbhai Soni, Gujarat (IN); and Abhishek Tiwari, Gujarat (IN)
Assigned to SUN PHARMACEUTICAL INDUSTRIES LIMITED, Maharashtra (IN)
Filed by Sun Pharmaceutical Industries Limited, Maharashtra (IN)
Filed on Aug. 12, 2022, as Appl. No. 17/819,466.
Application 17/819,466 is a continuation of application No. 17/134,982, filed on Dec. 28, 2020, granted, now 11,485,766.
Application 17/134,982 is a continuation of application No. 16/376,190, filed on Apr. 5, 2019, granted, now 11,447,535.
Claims priority of application No. 201821013109 (IN), filed on Apr. 5, 2018; application No. 201821040468 (IN), filed on Oct. 26, 2018; and application No. 201821040474 (IN), filed on Oct. 26, 2018.
Prior Publication US 2022/0402992 A1, Dec. 22, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/605 (2006.01); A61K 9/00 (2006.01); A61P 3/10 (2006.01); A61P 3/04 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/605 (2013.01) [A61K 9/0053 (2013.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); A61K 38/00 (2013.01)] 7 Claims
 
1. A Glucagon-like Peptide-1 (GLP-1) agonist peptide or salt thereof comprising a modification, wherein the modification is a group of formula (I) attached to an amino acid residue in the peptide

OG Complex Work Unit Chemistry
wherein
U represents —C(O)—CH2—O—(CH2)2—O—(CH2)2—NH—} wherein } is point of attachment to W;
W represents
—C(O)—NH—(CH2)3-4—NH—],
—C(O)—C(CH3)2—NH—], or

OG Complex Work Unit Chemistry
wherein ] is point of attachment to Y;
Y represents —C(O)—(CH2)2—CH(COOH)NH— and — is point of attachment to Z;
Z represents —C(O)—(CH2)n—COOH or —C(O)—(CH2)n—CH3 wherein n is an integer from 14-20.