CPC C07K 14/47 (2013.01) [A61K 35/16 (2013.01); A61K 38/00 (2013.01); A61K 38/04 (2013.01); A61K 38/12 (2013.01); A61K 38/16 (2013.01); A61K 38/38 (2013.01); A61K 38/42 (2013.01); C07K 14/515 (2013.01); C07K 14/76 (2013.01); C07K 14/765 (2013.01); C12N 15/00 (2013.01); A61K 9/1275 (2013.01); C07K 14/775 (2013.01)] | 15 Claims |
1. A mutant angiopoietin-like protein 4 (Angptl4) polypeptide having decreased LPL inhibitory activity, increased resistance to cleavage, or a combination of the foregoing, wherein the mutant Angptl4 polypeptide has at least 95% sequence identity with SEQ ID NO: 9 or SEQ ID NO: 10 and wherein positions 39 and 40 of SEQ ID NO: 9 or SEQ ID NO: 10 are selected from the group consisting of: DK, DA, KE and AE, positions 76 and 80 of SEQ ID NO: 9 or SEQ ID NO: 10 are selected from the group consisting of: C, S, and A, and positions 161-164 of SEQ ID NO: 9 or SEQ ID NO: 10 are selected from the group consisting of: GAAG (SEQ ID NO: 29), AAVV (SEQ ID NO: 69), GVVA (SEQ ID NO: 49), SGGG (SEQ ID NO: 87), and VAVA (SEQ ID NO: 90).
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