CPC C07K 14/43522 (2013.01) [A61K 45/06 (2013.01); A61K 47/64 (2017.08); A61K 47/65 (2017.08); A61P 35/00 (2018.01); C07K 19/00 (2013.01)] | 22 Claims |
1. A composition comprising a peptide-immuno-oncology agent complex, the peptide-immuno-oncology agent complex comprising a peptide complexed with an immuno-oncology agent, wherein the peptide of the peptide-immuno-oncology agent complex comprises:
at least 4 cysteine residues, and
a plurality of disulfide bridges formed between the cysteine residues;
wherein the peptide is tumor-homing,
wherein the immuno-oncology agent comprises an IL-15 agent, and
wherein the peptide-immuno-oncology agent complex comprises:
a) SEQ ID NO: 1330;
b) SEQ ID NO: 1340; or
c) any one of SEQ ID NO: 1317, SEQ ID NO: 1328, SEQ ID NO: 1435, SEQ ID NO: 1437, or SEQ ID NO: 1441.
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