CPC C07K 14/315 (2013.01) [A61K 47/64 (2017.08); A61K 47/6415 (2017.08); C07K 1/1072 (2013.01); C07K 1/1077 (2013.01); C07K 19/00 (2013.01); C12N 9/1205 (2013.01); C12N 9/1241 (2013.01); C12N 9/52 (2013.01); C12N 15/62 (2013.01); C12Q 1/68 (2013.01); C07K 2319/03 (2013.01); C07K 2319/20 (2013.01); C12Y 207/07 (2013.01)] | 9 Claims |
1. A composition comprising a modified pore-forming protein of structural formula (IVa)
wherein,
S is a sulfur atom of a thiol group of the pore forming protein;
A is a thiol reactive group;
LA is a linker; and
X is a click chemistry reactive group;
Y is a click chemistry reactive group that undergoes a click chemistry reaction with the reactive group X;
LB is a linker; and
B is a reactive group, wherein the reactive group B comprises a SpyTag peptide or a SpyCatcher protein.
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