CPC C07J 5/0015 (2013.01) [A61P 15/00 (2018.01); A61P 15/06 (2018.01); A61P 15/12 (2018.01); C07B 2200/13 (2013.01)] | 11 Claims |
1. A cocrystal of progesterone, characterized in that the cocrystal of progesterone is formed by the active ingredient progesterone and a cocrystal former, which is selected from the group consisting of isophthalic acid, 4-formylbenzeneboronic acid, and 3-nitrophthalic acid;
wherein when the cocrystal former is isophthalic acid, powder X-ray diffraction characteristic peaks of the resulting progesterone-isophthalic acid cocrystal, expressed as 2θ angles, appear at 6.56°, 10.96°, 13.14°, 16.17°, 19.76°, 20.32°, 21.04°, 22.20°, 24.17°, 26.45°, 28.05°, and 28.55°;
wherein when the cocrystal former is 4-formylbenzeneboronic acid, powder X-ray diffraction characteristic peaks of the resulting progesterone-4-formylbenzeneboronic acid cocrystal, expressed as 2θ angles, appear at 9.04°, 10.55°, 12.64°, 13.44°, 15.53°, 16.48°, 16.99°, 18.22°, 19.11°, 19.66°, 20.70°, 21.18°, 22.12°, 23.48°, 24.68°, 26.63°, and 27.85°;
wherein when the cocrystal former is 3-nitrophthalic acid, powder X-ray diffraction characteristic peaks of the resulting progesterone-3-nitrophthalic acid cocrystal, expressed as 2θ angles, appear at 9.08°, 13.01°, 13.39°, 13.78°, 15.88°, 16.55°, 18.78°, 19.29°, 20.87°, 23.34°, 26.27°, 27.33° and 29.79°.
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