US 11,866,455 B2
Gold(III) complex, a conjugate of the gold(III) complex, a pharmaceutical composition comprising the gold(III) complex and uses and a process for preparing the gold(III) complex
Sara Maria Soto Gonzalez, Terrassa (ES); Carlos Ratia Loncan, Barcelona (ES); Virginio Cepas Lopez, Sabadell (ES); Yuly Lopez Cubillos, Barcelona (ES); Fernando Lopez Ortiz, Almeria (ES); Maria Jose Iglesias Valdes-Solis, Almeria (ES); and Raquel Maria Gonzalez Soengas, Retamar (ES)
Appl. No. 17/050,512
Filed by UNIVERSIDAD DE ALMERIA, Almeria (ES); and FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA, Barcelona (ES)
PCT Filed Apr. 29, 2019, PCT No. PCT/EP2019/060879
§ 371(c)(1), (2) Date Oct. 26, 2020,
PCT Pub. No. WO2019/211222, PCT Pub. Date Nov. 7, 2019.
Claims priority of application No. 18382305 (EP), filed on May 3, 2018.
Prior Publication US 2021/0188886 A1, Jun. 24, 2021
Int. Cl. C07F 9/6558 (2006.01); A61P 31/04 (2006.01); A01N 57/02 (2006.01); A01N 57/08 (2006.01); C07F 9/54 (2006.01); C07F 9/572 (2006.01); C07F 9/59 (2006.01)
CPC C07F 9/6558 (2013.01) [A01N 57/02 (2013.01); A01N 57/08 (2013.01); A61P 31/04 (2018.01); C07F 9/5463 (2013.01); C07F 9/572 (2013.01); C07F 9/59 (2013.01)] 6 Claims
 
1. A pharmaceutically acceptable salt of a gold(III) complex, having formula (I):

OG Complex Work Unit Chemistry
wherein:
R1 is independently selected from aryl and amine;
R2 is independently selected from alkyl and cycloalkyl;
R3 is independently selected from hydrogen, halogen, nitro, cyano, alkyl, alkyloxy, alkylamino, aminodialkyl, hydroxyalkyl, trialkylsilyl, aryldialkylsilyl, alkylthio, cycloalkyl, aryl, heterocycle, polycycle, amino acid, and peptide; and
R4 is independently selected from alkyl, cycloalkyl, alkylalkoxy, alkylamino, dialkylamino, aliphatic amine, alkylthio, trialkylphosphino, dialkylarylphosphino, alkyldiarylphosphino, triarylphosphino, aryl, heterocycle, polycycle, amino acid and peptide.