CPC C07D 487/04 (2013.01) [A61P 33/06 (2018.01)] | 19 Claims |
1. A compound having the structure:
R1 is optionally substituted aryl or heteroaryl;
R2 is optionally substituted alkoxy, cycloalkoxy or heterocyclyl;
R3 is hydrogen, or —CH2—X;
R4 and R5 are independently hydrogen, —X, or —CH2—X, and at least one of R4 and R5 is not hydrogen;
—X is independently selected at each occurrence from —OH, —OR, —S(O)R, —S(O)2R, —N(R)—S(O)2R, —S(O)2—N(R)(R), —S(O)2—NHR, —N(R)—C(O)—R, —NH2, or —N(R)(R); and
R is independently at each occurrence an optionally substituted C1-C12 alkyl;
or a pharmaceutically acceptable salt thereof.
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