US 11,866,439 B2
Ion channel modulators
Andrew Mark Griffin, L'lle Bizard (CA); Brian Edward Marron, Ada, MI (US); Gabriel Martinez Botella, Wayland, MA (US); Kiran Reddy, Boston, MA (US); and Marion Wittmann, Medford, MA (US)
Assigned to PRAXIS PRECISION MEDICINES, INC., Boston, MA (US)
Appl. No. 17/058,187
Filed by Praxis Precision Medicines, Inc., Cambridge, MA (US)
PCT Filed May 30, 2019, PCT No. PCT/US2019/034653
§ 371(c)(1), (2) Date Nov. 24, 2020,
PCT Pub. No. WO2019/232209, PCT Pub. Date Dec. 5, 2019.
Claims priority of provisional application 62/738,508, filed on Sep. 28, 2018.
Claims priority of provisional application 62/677,903, filed on May 30, 2018.
Prior Publication US 2021/0163488 A1, Jun. 3, 2021
Int. Cl. C07D 487/04 (2006.01); A61P 23/00 (2006.01); A61P 25/08 (2006.01); C07D 471/04 (2006.01)
CPC C07D 487/04 (2013.01) [A61P 23/00 (2018.01); A61P 25/08 (2018.01); C07D 471/04 (2013.01); C07B 2200/13 (2013.01)] 14 Claims
 
1. A crystalline form of compound:

OG Complex Work Unit Chemistry
wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising X-ray powder diffraction peaks at the following diffraction angles (° 2θ): 12.6±0.2, 15.8±0.2, and 18.6±0.2.