CPC C07D 471/04 (2013.01) [C07B 2200/13 (2013.01)] | 41 Claims |
1. A crystalline form of the compound of formula 1, or a pharmaceutically acceptable salt thereof:
wherein:
the compound of formula 1 is the free base sesquihydrate of the compound of formula 1 having Form I, which has at least one XRPD peak, in terms of 2-theta (±0.2 degrees), selected from 7.0, 8.5, 10.0, 10.6, 14.6, 15.2, 15.8, 17.2, 20.1, 21.1, 23.9, 24.8, 26.1, 28.1, 29.6, and 30.2 degrees;
the compound of formula 1 is the free base of the compound of formula 1 having Form II, which has at least one XRPD peaks, in terms of 2-theta (±0.2 degrees), selected from 8.5, 15.0, 15.7, 17.0, 18.6, 20.2, 20.5, 21.7, 25.5, and 26.7 degrees; or
the compound of formula 1 is a methanesulfonic acid salt having Form III, which has at least one XRPD peaks, in terms of 2-theta (±0.2 degrees), selected from 5.2, 7.5, 8.2, 8.8, 9.4, 11.6, 12.4, 13.0, 14.0, 14.8, 15.8, 16.6, 16.9, 17.3, 17.9, 19.2, 23.6, 24.5, 25.5, and 26.6 degrees.
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