US 11,866,412 B1
Acridin-9-one compounds as antibacterial agents
Christophe Tratrat, Al-Ahsa (SA); and Michelyne Haroun, Al-Ahsa (SA)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Mar. 3, 2023, as Appl. No. 18/116,920.
Int. Cl. C07D 219/06 (2006.01); C07D 471/04 (2006.01)
CPC C07D 219/06 (2013.01) [C07D 471/04 (2013.01)] 18 Claims
 
1. An acridin-9-one compound having the formula I:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, ester stereoisomer, or solvate thereof, wherein:
each X is independently CH or nitrogen;
R1 is H, C1-C6 alkyl, or C3-C8 cycloalkyl;
R2 is H or a halogen;
R3 and R4 may independently be the same or different and are of H, —CO2R, —OR, —CF3, —OCF3, —CH2NR′R″, —CONR′R″, —CH2CO2R, —CH2OH, —SO2NHR, or —SO2R; and
R, R′, and R″ may each independently be H or C1-C6 alkyl.