US 11,865,475 B2
Acoustically settled liquid-liquid sample purification system and method of use
Scott P. Collins, Ogden, UT (US); Christopher D. Brau, Logan, UT (US); and Nephi D. Jones, Newton, UT (US)
Assigned to Life Technologies Corporation, Carlsbad, CA (US)
Filed by LIFE TECHNOLOGIES CORPORATION, Carlsbad, CA (US)
Filed on Nov. 8, 2021, as Appl. No. 17/521,445.
Application 16/819,951 is a division of application No. 15/521,227, granted, now 10,610,804, issued on Apr. 7, 2020, previously published as PCT/US2015/057095, filed on Oct. 23, 2015.
Application 17/521,445 is a continuation of application No. 16/819,951, filed on Mar. 16, 2020, granted, now 11,173,417.
Claims priority of provisional application 62/068,410, filed on Oct. 24, 2014.
Prior Publication US 2022/0054954 A1, Feb. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. B01D 11/04 (2006.01); B01F 31/00 (2022.01); B01F 31/60 (2022.01); B01F 33/80 (2022.01); G01N 1/34 (2006.01); G01N 1/40 (2006.01)
CPC B01D 11/0423 (2013.01) [B01D 11/043 (2013.01); B01D 11/0449 (2013.01); B01D 11/0457 (2013.01); B01F 31/56 (2022.01); B01F 31/60 (2022.01); B01F 33/80 (2022.01); G01N 1/34 (2013.01); G01N 2001/4061 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A method of purifying a sample in a two-phase system, the method comprising:
mixing a first liquid with a second liquid to form a first mixture, the first liquid comprising a first liquid phase, the second liquid comprising a second liquid phase, the second liquid being immiscible in the first liquid, the first mixture comprising a portion of the second liquid dispersed in the first liquid;
settling a first portion of the first mixture; and
applying an acoustic wave to the settled first portion of the first mixture to form a first acoustically settled mixture;
wherein the step of applying the acoustic wave occurs in an acoustic settling loop, the acoustic settling loop having a first end in fluid communication with a settling zone and a second end in fluid communication with the settling zone.