US 11,865,365 B2
Systems and methods for personalized radiation therapy
Jacob G. Scott, Gates Mills, OH (US); and Javier Torres-Roca, St. Petersburg, FL (US)
Assigned to CVERGENX, INC., St. Petersburg, FL (US)
Filed by CVERGENX, INC., St. Petersburg, FL (US)
Filed on Dec. 30, 2022, as Appl. No. 18/148,502.
Application 18/148,502 is a continuation of application No. 16/658,961, filed on Oct. 21, 2019, granted, now 11,547,871.
Claims priority of provisional application 62/747,861, filed on Oct. 19, 2018.
Prior Publication US 2023/0248995 A1, Aug. 10, 2023
Int. Cl. A61N 5/10 (2006.01); C12Q 1/6883 (2018.01)
CPC A61N 5/1031 (2013.01) [C12Q 1/6883 (2013.01); A61N 2005/1032 (2013.01); C12Q 2600/158 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A computer software configured to integrate with a radiation therapy treatment planning system, the computer software being configured to:
assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor;
calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and
provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan,
wherein the computer software is embodied on a non-transitory computer readable medium, and
wherein the pre-determined GARD value is about 33 for non-small cell lung cancer.