US 11,865,324 B2
Injection devices
Rolf Hoffmann, Freiburg (DE); and Martin Hohlrieder, Feldkrich (AT)
Assigned to RepliCel Life Sciences Inc., Vancouver (CA)
Filed by RepliCEL Life Sciences Inc., Vancouver (CA)
Filed on May 24, 2021, as Appl. No. 17/328,951.
Application 17/328,951 is a division of application No. 15/501,171, granted, now 11,045,612, previously published as PCT/US2015/044110, filed on Aug. 6, 2015.
Claims priority of provisional application 62/198,655, filed on Jul. 29, 2015.
Claims priority of provisional application 62/034,140, filed on Aug. 6, 2014.
Prior Publication US 2021/0346611 A1, Nov. 11, 2021
Int. Cl. A61M 5/44 (2006.01); A61M 5/32 (2006.01); A61M 5/42 (2006.01); A61M 5/46 (2006.01); A61M 5/24 (2006.01); A61M 5/315 (2006.01); A61M 5/19 (2006.01); A61M 5/20 (2006.01); A61M 5/31 (2006.01)
CPC A61M 5/44 (2013.01) [A61M 5/19 (2013.01); A61M 5/20 (2013.01); A61M 5/24 (2013.01); A61M 5/31515 (2013.01); A61M 5/31546 (2013.01); A61M 5/3202 (2013.01); A61M 5/3298 (2013.01); A61M 5/422 (2013.01); A61M 5/46 (2013.01); A61M 2005/247 (2013.01); A61M 2005/2411 (2013.01); A61M 2005/3126 (2013.01); A61M 2005/31588 (2013.01); A61M 2202/09 (2013.01); A61M 2205/13 (2013.01); A61M 2205/3327 (2013.01); A61M 2205/3344 (2013.01); A61M 2205/3368 (2013.01); A61M 2205/3379 (2013.01); A61M 2205/3569 (2013.01); A61M 2205/3606 (2013.01); A61M 2205/3673 (2013.01); A61M 2205/50 (2013.01); A61M 2205/505 (2013.01); A61M 2205/52 (2013.01); A61M 2205/581 (2013.01); A61M 2205/583 (2013.01); A61M 2205/587 (2013.01); A61M 2205/6054 (2013.01); A61M 2205/6072 (2013.01); A61M 2205/8206 (2013.01); A61M 2209/086 (2013.01)] 2 Claims
OG exemplary drawing
 
1. A method of delivering a liquid substance comprising cells into tissue, the method comprising placing the liquid substance into an injection device and then injecting the liquid substance from the injection device and into the tissue;
wherein the injection device comprises a proximal end and a distal end, the distal end for introducing the liquid substance into a body of a subject, the injection device further comprising:
a) an injector comprising at least one needle and a housing for the at least one needle;
b) a cartridge comprising at least one chamber to hold the liquid substance, and a plunger which moves within the chamber to change a volume of the chamber; and
c) a delivery mechanism to independently move the plunger and the at least one needle toward the distal end of the device, the delivery mechanism comprising means for adjusting the volume of the cartridge to inject the liquid substance through the at least one needle and an electromechanical drive device arranged to advance and retract the at least one needle, wherein the means for adjusting the volume of the cartridge and the electromechanical drive device are operable independently, so that the volume of the cartridge can be adjusted to inject the liquid substance through the at least one needle while the at least one needle is being retracted, the delivery mechanism comprising a distal drive that is movable relative to the proximal end of the injection device, a proximal drive that is stationary relative to the proximal end of the injection device and a threaded rod that joins the proximal and distal drives and the plunger;
wherein the liquid substance is injected into the body while the at least one needle is being retracted.