US 11,865,228 B2
Bone void filler and method for manufacturing the same by natural calcium-containing waste
Wen-Fu Ho, Kaohsiung (TW); Hui-Chun Yu, Kaohsiung (TW); Shih-Ching Wu, Kaohsiung (TW); Hsueh-Chuan Hsu, Kaohsiung (TW); Chi-Jen Chung, Kaohsiung (TW); and Shih-Kuang Hsu, Kaohsiung (TW)
Assigned to National University Of Kaohsiung, Kaohsiung (TW)
Filed by NATIONAL UNIVERSITY OF KAOHSIUNG, Kaohsiung (TW)
Filed on Jul. 2, 2021, as Appl. No. 17/366,721.
Prior Publication US 2023/0001050 A1, Jan. 5, 2023
Int. Cl. A61L 27/36 (2006.01); A61L 27/20 (2006.01); A61L 27/12 (2006.01); A61L 27/56 (2006.01)
CPC A61L 27/365 (2013.01) [A61L 27/12 (2013.01); A61L 27/20 (2013.01); A61L 27/3637 (2013.01); A61L 27/3687 (2013.01); A61L 27/3691 (2013.01); A61L 27/56 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method for manufacturing a bone void filler by a natural calcium-containing waste, comprising steps of:
(a) uniformly mixing 5-20 wt % of a powder of calcium-containing waste, 5-20 wt % of acetic acid and a remaining weight percentage of water to obtain a mixing solution, wherein the powder of calcium-containing waste comprises an eggshell powder, a shell powder of Crustacea animals, a shell powder of Bivalvia animals or a shell powder of Gastropoda animals;
(b) adding 5-20 vol % of a diammonium hydrogen phosphate solution into the mixing solution to obtain a suspension;
(c) controlling a pH value of the suspension between 7.5 and 14 to obtain an alkaline solution;
(d) leaving the alkaline solution at room temperature for precipitation for 0.1-72 hours, preforming a centrifugal process or a suction filtration process on the alkaline solution to obtain a precipitate, drying and grinding the precipitate to obtain a hydroxyapatite; and
(e) uniformly mixing 30-60 wt % of a pore former, 30-60 wt % of the hydroxyapatite and a remaining weight percentage of a binder to form a mixture, compression molding the mixture in a mold and then sintering the compression-molded mixture at a sintering temperature to obtain the bone void filler.