US 11,865,224 B2
Delivery systems based on hydrogel compositions and methods thereof
Jie Song, Shrewsbury, MA (US); Yu Tan, Worcester, MA (US); and Henry Huang, Somerville, MA (US)
Assigned to University of Massachusetts, Boston, MA (US)
Filed by University of Massachusetts, Boston, MA (US)
Filed on May 2, 2022, as Appl. No. 17/734,796.
Application 17/734,796 is a division of application No. 16/756,455, granted, now 11,357,887, previously published as PCT/US2018/060236, filed on Nov. 11, 2018.
Claims priority of provisional application 62/584,402, filed on Nov. 10, 2017.
Prior Publication US 2022/0323643 A1, Oct. 13, 2022
Int. Cl. A61L 27/18 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); C08L 71/02 (2006.01)
CPC A61L 27/18 (2013.01) [A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 2400/06 (2013.01); C08L 71/02 (2013.01)] 12 Claims
 
1. A method for delivering a biologically active payload, comprising,
placing in a subject in need thereof a device or implant, wherein the device or implant comprises a hydrogel comprising a 3-dimensional crosslinking network of a combination of covalent crosslinking (CX) and non-covalent crosslinking (NCX) of hydrophilic branched polymers,

OG Complex Work Unit Chemistry
wherein the hydrophilic branched polymers are star-branched with at least 3 arms; and
causing a controlled release of the biologically active payload.