US 11,865,185 B2
RAAV with chemically modified capsid
Mathieu Mevel, Nantes (FR); David Deniaud, Nantes (FR); and Eduard Ayuso, Nantes (FR)
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris (FR); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR); NANTES UNIVERSITE, Nantes (FR); and CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES, Nantes (FR)
Appl. No. 16/308,740
Filed by CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris (FR); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR); UNIVERSITE DE NANTES, Nantes (FR); and CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES, Nantes (FR)
PCT Filed Jun. 9, 2017, PCT No. PCT/EP2017/064089
§ 371(c)(1), (2) Date Dec. 10, 2018,
PCT Pub. No. WO2017/212019, PCT Pub. Date Dec. 14, 2017.
Claims priority of application No. 16305681 (EP), filed on Jun. 9, 2016.
Prior Publication US 2019/0388557 A1, Dec. 26, 2019
Int. Cl. C12N 7/00 (2006.01); A61K 39/23 (2006.01); A61K 47/69 (2017.01); A61K 48/00 (2006.01); A61K 49/18 (2006.01)
CPC A61K 47/6901 (2017.08) [A61K 48/0091 (2013.01); A61K 49/1896 (2013.01); C12N 7/00 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14133 (2013.01); C12N 2750/14134 (2013.01); C12N 2750/14142 (2013.01); C12N 2750/14143 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein said ligand L is implemented under the form of a compound of formula (I)

OG Complex Work Unit Chemistry
with
N* being the nitrogen atom of one primary amino group contained in the capsid proteins, and

OG Complex Work Unit Chemistry
representing an optionally substituted arylene or a heteroarylene radical, directly or not, covalently bound to at least one ligand L.