	US 11,865,178 B2
	Dermal applicator for use in cancer photoimmunotherapy
Zhen Gu, Raleigh, NC (US); and Yanqi Ye, Raleigh, NC (US)
Assigned to North Carolina State University, Raleigh, NC (US)
Appl. No. 16/759,035
Filed by North Carolina State University, Raleigh, NC (US)
PCT Filed Oct. 25, 2018, PCT No. PCT/US2018/057494 § 371(c)(1), (2) Date Apr. 24, 2020, PCT Pub. No. WO2019/084259, PCT Pub. Date May 2, 2019.
Claims priority of provisional application 62/576,774, filed on Oct. 25, 2017.
Prior Publication US 2021/0177968 A1, Jun. 17, 2021
Int. Cl. A61K 41/00 (2020.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01); A61K 9/00 (2006.01); A61K 31/407 (2006.01); A61K 38/19 (2006.01); A61K 45/06 (2006.01); A61K 47/36 (2006.01); A61N 5/06 (2006.01); A61N 5/067 (2006.01)

CPC A61K 41/0057 (2013.01) [A61K 9/0021 (2013.01); A61K 31/407 (2013.01); A61K 38/193 (2013.01); A61K 39/0011 (2013.01); A61K 39/00119 (2018.08); A61K 45/06 (2013.01); A61K 47/36 (2013.01); A61N 5/062 (2013.01); A61P 35/00 (2018.01); A61N 5/067 (2021.08); A61N 2005/0659 (2013.01)]

17 Claims

1. A photo-responsive dermal applicator for use in photoimmunotherapy, the dermal applicator comprising:

a transdermal microneedle array comprising a plurality of microneedles, each microneedle comprising a base portion and a tip portion, wherein the tip portion is distal to the base portion;

an immunogenic composition comprising at least one tumor antigen;

an immunostimulant; and

a photo-sensitive biological pigment comprising melanin;

wherein the immunogenic composition, the immunostimulant, and the photo-sensitive biological pigment are encapsulated within the transdermal microneedle array using a polymeric matrix comprising hyaluronic acid, wherein the immunogenic composition and the photo-sensitive biological pigment are encapsulated within the base portion of the plurality of microneedles, and wherein the immunostimulant is encapsulated within the tip portion of the plurality of microneedles.