US 11,865,177 B2
Composition and methods for stabilizing liquid protein formulations
Anthony Tomlinson, South San Francisco, CA (US); Barthelemy Luc Demeule, South San Francisco, CA (US); and Isidro Angelo Eleazar Zarraga, Millbrae, CA (US)
Assigned to GENENTECH, INC., South San Francisco, CA (US)
Filed by Genentech, Inc., South San Francisco, CA (US)
Filed on Jun. 26, 2020, as Appl. No. 16/914,100.
Claims priority of provisional application 62/868,615, filed on Jun. 28, 2019.
Prior Publication US 2021/0015920 A1, Jan. 21, 2021
Int. Cl. A61K 39/395 (2006.01); A61K 9/08 (2006.01); A61K 9/19 (2006.01); A61K 47/22 (2006.01)
CPC A61K 39/39591 (2013.01) [A61K 9/08 (2013.01); A61K 9/19 (2013.01); A61K 47/22 (2013.01)] 35 Claims
 
1. A liquid formulation comprising a polypeptide and a surfactant, wherein at least about 70% (wt %) of the surfactant are isosorbide polyoxyethylene (POE) fatty acid esters.