US 11,865,108 B2
Nitrogen containing bicyclic compounds
Vijaykumar Jagdishwar Patil, Solapur (IN); Ravikumar Tadiparthi, Vijayawada (IN); Rajib Bhuniya, Burdwan (IN); Vikas Vitthalrao Deshmukh, Ahmednagar (IN); Zaki Ahmed Burhanuddin Munshi, Kalyan (IN); Piyush Ambalal Patel, Anand (IN); Prashant Ratnakar Joshi, Parbhani (IN); Rajesh Chavan, Aurangabad (IN); Swapna Shripad Takalkar, Aurangabad (IN); Ravindra Dattatraya Yeole, Aurangabad (IN); and Mahesh Vithalbhai Patel, Aurangabad (IN)
Assigned to Wockhardt Limited, Aurangabad (IN)
Appl. No. 17/769,338
Filed by Wockhardt Limited, Aurangabad (IN)
PCT Filed Oct. 18, 2020, PCT No. PCT/IN2020/050890
§ 371(c)(1), (2) Date Apr. 15, 2022,
PCT Pub. No. WO2021/074930, PCT Pub. Date Apr. 22, 2021.
Claims priority of application No. 201921042452 (IN), filed on Oct. 18, 2019.
Prior Publication US 2022/0378759 A1, Dec. 1, 2022
Int. Cl. C07D 471/08 (2006.01); A61K 31/439 (2006.01); A61P 31/04 (2006.01); A61K 31/546 (2006.01)
CPC A61K 31/439 (2013.01) [A61K 31/546 (2013.01); A61P 31/04 (2018.01); C07D 471/08 (2013.01)] 14 Claims
 
1. A compound of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein:
B is selected from:
(a) hydrogen,
(b) halogen,
(c) C1-C6 alkyl,
(d) OR1,
(e) NR1R2,
(f) SH,
(g) SR1,
(h) SOR1,
(i) SO2R1,
(j) CHO,
(k) COOR1,
(l) CONR1R2,
(m) CN,
(n) heteroaryl,
(o) heterocycloalkyl, or
(P) NHC(═NH)NH2;
R1 and R2 are each independently:
(a) hydrogen,
(b) C1-C6 alkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, SH, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl,
(c) three to seven membered cycloalkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, or SH,
(d) three to seven membered heterocycloalkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, or SH,
(e) six to fourteen membered aryl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, or SH, or
(f) five to fourteen membered heteroaryl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, SH;
M is selected from:
(a) hydrogen,
(b) C1-C6 alkyl, or
(c) a pharmaceutically accepted salt forming cation independently selected from Na, K, or Ca.