CPC A61K 31/439 (2013.01) [A61K 31/546 (2013.01); A61P 31/04 (2018.01); C07D 471/08 (2013.01)] | 14 Claims |
1. A compound of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof:
wherein:
B is selected from:
(a) hydrogen,
(b) halogen,
(c) C1-C6 alkyl,
(d) OR1,
(e) NR1R2,
(f) SH,
(g) SR1,
(h) SOR1,
(i) SO2R1,
(j) CHO,
(k) COOR1,
(l) CONR1R2,
(m) CN,
(n) heteroaryl,
(o) heterocycloalkyl, or
(P) NHC(═NH)NH2;
R1 and R2 are each independently:
(a) hydrogen,
(b) C1-C6 alkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, SH, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl,
(c) three to seven membered cycloalkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, or SH,
(d) three to seven membered heterocycloalkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, or SH,
(e) six to fourteen membered aryl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, or SH, or
(f) five to fourteen membered heteroaryl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH2, COOH, CONH2, SH;
M is selected from:
(a) hydrogen,
(b) C1-C6 alkyl, or
(c) a pharmaceutically accepted salt forming cation independently selected from Na, K, or Ca.
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