CPC A61K 31/135 (2013.01) [A61K 9/0053 (2013.01); A61K 9/167 (2013.01); A61K 9/1611 (2013.01); A61K 9/1623 (2013.01); A61K 9/1635 (2013.01); A61K 9/1652 (2013.01); A61K 31/136 (2013.01); A61K 31/15 (2013.01); A61K 31/343 (2013.01); A61K 31/36 (2013.01); A61K 31/381 (2013.01); A61K 31/7034 (2013.01); A61P 25/24 (2018.01)] | 17 Claims |
1. A method of treating major depressive disorder (MDD) in a
human patient in need thereof consisting essentially of orally administering to said patient an oral dosage form of between 20 mg and 40 mg of esketamine over a treatment regimen of at least 28 days;
and optionally administering to said patient a second medication that is an antidepressant, an antimanic agent, or an anxiolytic drug that does not alter the metabolism of the esketamine in the patient,
wherein the ratio of S-norketamine Cmax to esketamine Cmax after the co-administration of the esketamine and the second medication is at least 6.
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