US 11,864,906 B2
LIDAR implantable biosensor for imaging biological tissue
Steven J. Holmes, Ossining, NY (US); Devendra K. Sadana, Pleasantville, NY (US); and Stephen W. Bedell, Wappingers Falls, NY (US)
Assigned to International Business Machines Corporation, Armonk, NY (US)
Filed by International Business Machines Corporation, Armonk, NY (US)
Filed on Jun. 20, 2019, as Appl. No. 16/447,324.
Prior Publication US 2020/0397362 A1, Dec. 24, 2020
Int. Cl. A61B 5/00 (2006.01)
CPC A61B 5/4064 (2013.01) [A61B 5/0031 (2013.01); A61B 5/0084 (2013.01); A61B 5/742 (2013.01); A61B 2562/0233 (2013.01); A61B 2562/046 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method, comprising:
implanting an implantable biosensor within a subject, the implantable biosensor comprising an array of light sources and an array of light detectors disposed on a semiconductor substrate, wherein the array of light sources and the array of light detectors are each positioned in spaced relation relative to the semiconductor substrate;
activating the array of light sources to direct light signals at a targeted tissue site in the subject;
capturing, with the array of light detectors, the light signals reflected off the targeted tissue site;
calculating a roundtrip propagation time for each of the light signals; and
comparing the roundtrip propagation time for each of the light signals against one or more corresponding prior roundtrip propagation times to determine an occurrence of a change in a cell structure at the targeted tissue site;
wherein the one or more corresponding prior roundtrip propagation times are previously generated by and stored in an external system.