US 11,862,445 B2
Imaging mass spectrometer
Shinichi Yamaguchi, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Appl. No. 17/312,502
Filed by SHIMADZU CORPORATION, Kyoto-shi (JP)
PCT Filed Feb. 14, 2019, PCT No. PCT/JP2019/005366
§ 371(c)(1), (2) Date Jun. 10, 2021,
PCT Pub. No. WO2020/166007, PCT Pub. Date Aug. 20, 2020.
Prior Publication US 2022/0051884 A1, Feb. 17, 2022
Int. Cl. H01J 49/00 (2006.01)
CPC H01J 49/0004 (2013.01) [H01J 49/0036 (2013.01)] 6 Claims
OG exemplary drawing
 
1. An imaging mass spectrometer that executes mass spectrometry on each of a plurality of micro areas set in a two-dimensional measurement region on a sample or a three-dimensional measurement region in a sample, the imaging mass spectrometer comprising:
a mass spectrometry imaging graphic data acquisition section configured to acquire data constituting a plurality of first imaging graphics indicating an ion intensity distribution at one or a plurality of specific mass-to-charge ratios or in one or a plurality of mass-to-charge ratio ranges based on data obtained by mass spectrometry for a target sample;
a second imaging graphic data acquisition section configured to acquire data constituting a plurality of second imaging graphics obtained by an analysis method of a type different from the mass spectrometry with respect to the target sample;
a first data processor configured to perform, on data acquired by the mass spectrometry imaging graphic data acquisition section and the second imaging graphic data acquisition section, data conversion processing of normalizing signal intensity in the plurality of first imaging graphics and signal intensity in the plurality of second imaging graphics;
a second data processor configured to perform, on data acquired by the mass spectrometry imaging graphic data acquisition section and the second imaging graphic data acquisition section, data processing of aligning spatial resolutions of the plurality of first imaging graphics and the plurality of second imaging graphics; and
an image classification processor configured to execute statistical analysis processing on images for data after processing by the first and second data processor and to classify the plurality of first imaging graphics and the plurality of second imaging graphics on a basis of similarity or difference in spatial distribution.