US 11,860,142 B2
Liquid chromatograph mass spectrometer
Masuyuki Sugiyama, Tokyo (JP); Yuichiro Hashimoto, Tokyo (JP); and Hideki Hasegawa, Tokyo (JP)
Assigned to HITACHI HIGH-TECH CORPORATION, Tokyo (JP)
Appl. No. 17/296,317
Filed by Hitachi High-Tech Corporation, Tokyo (JP)
PCT Filed Oct. 25, 2019, PCT No. PCT/JP2019/042053
§ 371(c)(1), (2) Date May 24, 2021,
PCT Pub. No. WO2020/121660, PCT Pub. Date Jun. 18, 2020.
Claims priority of application No. 2018-230775 (JP), filed on Dec. 10, 2018.
Prior Publication US 2022/0050091 A1, Feb. 17, 2022
Int. Cl. G01N 30/72 (2006.01); G01N 30/32 (2006.01); G01N 30/46 (2006.01); G01N 30/02 (2006.01); G01N 27/623 (2021.01)
CPC G01N 30/7266 (2013.01) [G01N 27/623 (2021.01); G01N 30/32 (2013.01); G01N 30/46 (2013.01); G01N 2030/027 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A liquid chromatograph mass spectrometer, comprising:
a first flow path that passes through a separation column;
a second flow path that does not pass through the separation column;
a mass spectrometry unit that is provided on a downstream side of the first flow path and the second flow path and analyzes a sample that has passed through the first flow path;
a first valve that connects any one of the first flow path and the second flow path to the mass spectrometry unit;
a first liquid feed pump that feeds liquid to the first flow path;
a second liquid feed pump that feeds liquid to the second flow path;
a controller that controls driving of the first valve, the first liquid feed pump, and the second liquid feed pump; and
a pressure gauge that measures a pressure of the second flow path and outputs the pressure to the controller,
wherein the controller is programmed to
connect the first flow path to the mass spectrometry unit when the sample is analyzed in the mass spectrometry unit and feed liquid to the mass spectrometry unit from the first liquid feed pump through the first flow path, and
connect the second flow path to the mass spectrometry unit, and drive the first valve, the first liquid feed pump, and the second liquid feed pump to feed liquid from the second liquid feed pump to the mass spectrometry unit through the second flow path in a case where it is determined to be abnormal when a measured value of the mass spectrometry unit and a predetermined threshold value are compared.