CPC C12Q 1/6886 (2013.01) [G16B 5/00 (2019.02); C12Q 2600/112 (2013.01)] | 13 Claims |
1. A method of analyzing nucleic acid sequences, the method comprising:
(a) sequencing amplified acellular DNA from a population of cancer patients subsequent to whole genome amplification of DNA extracted from serum or plasma from said population of cancer patients, wherein said sequencing is performed with one or more individual sequence tags for sample identification, and wherein said sequencing generates at least 50,000 sequences per sample;
(b) electrically receiving sequence information obtained in (a) on a processor describing one or more of the sequenced amplified acellular DNA from the population of cancer patients;
(c) electrically receiving sequence information on said processor describing one or more DNA sequences from a cancer free control population;
(d) electrically performing an analysis comparing the information electrically received on the processor in steps (b) and (c) within a finite number of cluster regions of the human genome by aligning sequences within the finite number of cluster regions from said sequenced acellular DNA from the population of cancer patients with one or more sequences from acellular DNA obtained from the cancer free control population; and
(e) electrically identifying one or more biomarkers representative of the type of cancer presented by the population of cancer patients by the processor.
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