US 11,858,997 B2
Amino acid sequences that modulate the interaction between cells of the immune system
Guy Hermans, Merelbeke (BE); Peter Verheesen, Ghent (BE); Edward Dolk, Utrecht (NL); Hendricus Renerus Jacobus Mattheus Hoogenboom, Maastricht (NL); Michael John Scott Saunders, Brussels (BE); Hans De Haard, Oudelande (NL); and Renee de Bruin, Amsterdam (NL)
Assigned to Ablynx N.V., Zwijnaarde (BE)
Filed by Ablynx N.V., Ghent-Zwijnaarde (BE)
Filed on Oct. 13, 2020, as Appl. No. 17/069,026.
Application 17/069,026 is a division of application No. 16/217,381, filed on Dec. 12, 2018, granted, now 10,844,123.
Application 16/217,381 is a division of application No. 15/050,740, filed on Feb. 23, 2016, granted, now 10,208,115.
Application 15/050,740 is a division of application No. 14/528,566, filed on Oct. 30, 2014, abandoned.
Application 14/528,566 is a continuation of application No. 12/448,260, granted, now 8,907,065, previously published as PCT/EP2007/011057, filed on Dec. 17, 2007.
Claims priority of provisional application 60/993,053, filed on Sep. 7, 2007.
Claims priority of provisional application 60/875,246, filed on Dec. 15, 2006.
Prior Publication US 2021/0139587 A1, May 13, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 47/64 (2017.01); C07K 14/76 (2006.01)
CPC C07K 16/2818 (2013.01) [A61K 47/643 (2017.08); C07K 14/76 (2013.01); C07K 16/2803 (2013.01); C07K 16/2827 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/31 (2013.01)] 21 Claims
 
1. A polypeptide that binds ICOSL and consists essentially of 4 framework regions (FR1 to FR4, respectively) and 3 complementarity determining regions (CDR1 to CDR3, respectively) in which:
CDR3 is chosen from the group consisting of:
a) the amino acid sequences of SEQ ID NOs: 491-497;
b) amino acid sequences that have at least 80% amino acid identity with at least one of the amino acid sequences of SEQ ID NOs: 491-497; and
c) amino acid sequences that have 3, 2 or 1 amino acid difference with at least one of the amino acid sequences of SEQ ID NOs: 491-497.