CPC C07K 16/2818 (2013.01) [A61K 47/643 (2017.08); C07K 14/76 (2013.01); C07K 16/2803 (2013.01); C07K 16/2827 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/31 (2013.01)] | 21 Claims |
1. A polypeptide that binds ICOSL and consists essentially of 4 framework regions (FR1 to FR4, respectively) and 3 complementarity determining regions (CDR1 to CDR3, respectively) in which:
CDR3 is chosen from the group consisting of:
a) the amino acid sequences of SEQ ID NOs: 491-497;
b) amino acid sequences that have at least 80% amino acid identity with at least one of the amino acid sequences of SEQ ID NOs: 491-497; and
c) amino acid sequences that have 3, 2 or 1 amino acid difference with at least one of the amino acid sequences of SEQ ID NOs: 491-497.
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