US 11,858,992 B2
Nucleic acids encoding antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
Vibeke Westphal Stennicke, Kokkedal (DK); Christine Brender Read, Soeborg (DK); Susanne Nedergaard Grell, Soeborg (DK); Charlotte Wiberg, Bjarred (SE); Rune Salbo, Hvidovre (DK); Anette Henriksen, Alleroed (DK); and Soeren Padkjaer, Vaeloese (DK)
Assigned to NOVO NORDISK A/S, Bagsvaerd (DK)
Filed by Novo Nordisk, Bagsvaerd (DK)
Filed on Feb. 1, 2021, as Appl. No. 17/163,666.
Application 17/163,666 is a division of application No. 16/209,627, filed on Dec. 4, 2018, granted, now 10,906,975.
Application 16/209,627 is a division of application No. 15/372,600, filed on Dec. 8, 2016, granted, now 10,189,904, issued on Jan. 29, 2019.
Application 15/372,600 is a continuation of application No. 13/954,318, filed on Jul. 30, 2013, granted, now 9,550,830, issued on Jan. 24, 2017.
Application 13/954,318 is a continuation in part of application No. 13/690,748, filed on Nov. 30, 2012, granted, now 9,000,127, issued on Apr. 7, 2015.
Claims priority of provisional application 61/674,434, filed on Jul. 23, 2012.
Claims priority of provisional application 61/672,799, filed on Jul. 18, 2012.
Claims priority of provisional application 61/599,447, filed on Feb. 16, 2012.
Claims priority of provisional application 61/598,968, filed on Feb. 15, 2012.
Claims priority of application No. 12155641 (EP), filed on Feb. 15, 2012; application No. 12158974 (EP), filed on Mar. 12, 2012; and application No. 12176892 (EP), filed on Jul. 18, 2012.
Prior Publication US 2021/0253697 A1, Aug. 19, 2021
Int. Cl. C07K 16/28 (2006.01); C12N 15/13 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2803 (2013.01) [A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 8 Claims
 
1. An isolated nucleic acid encoding an antibody or fragment thereof which binds to a triggering receptor expressed on myeloid cells-1 (TREM-1) having an amino acid sequence set forth as SEQ ID NO: 1 (human TREM-1), SEQ ID NO: 12 or SEQ ID NO: 21 (cynomolgus monkey TREM-1),
wherein the antibody or fragment thereof comprises a heavy chain variable region as set forth in SEQ ID NO: 4; and
wherein the antibody or fragment thereof comprises a light chain variable region as set forth in SEQ ID NO: 5.